期刊
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
卷 25, 期 -, 页码 26-34出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jgar.2021.02.020
关键词
Klebsiella pneumoniae; hvKP; CRKP; KPC; Virulence plasmid; Siderophore
资金
- National Natural Science Foundation of China [81672067, 81830069]
Hypervirulence and carbapenem resistance have emerged as two distinct evolutionary directions for Klebsiella pneumoniae, posing a great threat in clinical settings. CR-hvKP strains, integrating both phenotypes, have become increasingly prevalent globally, primarily in Asia. The mechanisms for the emergence of CR-hvKP can be summarised by three patterns, and continued surveillance of their dissemination should be highly prioritised.
Hypervirulence and carbapenem resistance have emerged as two distinct evolutionary directions for Klebsiella pneumoniae, which pose a great threat in clinical settings. Multiple virulence factors contribute to hypervirulence, and the mechanisms of carbapenem resistance are complicated. However, more and more K. pneumoniae strains have been identified in recent years integrating both phenotypes, resulting in devastating clinical outcomes. Hypervirulent and carbapenem-resistant K. pneumoniae (CR-hvKP) emerged in the early 2010s and thereafter have become increasingly prevalent. CR-hvKP are primarily prevalent in Asia, especially China, but are reported all over the world. Mechanisms for the emergence of CR-hvKP can be summarised by three patterns: (i) carbapenem-resistantK. pneumoniae (CRKP) acquiring a hypervirulent phenotype; (ii) hypervirulent K. pneumoniae (hvKP) acquiring a carbapenem-resistant phenotype; and (iii) K. pneumoniae acquiring both a carbapenem resistance and hypervirulence hybrid plasmid. With their global dissemination, continued surveillance of the emergence of CR-hvKP should be more highly prioritised. (c) 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/).
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