4.6 Review

Interplay Between Systemic Metabolic Cues and Autonomic Output: Connecting Cardiometabolic Function and Parasympathetic Circuits

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Summary: The nucleus tractus solitarii (nTS) plays a crucial role in integrating and terminating autonomic and respiratory sensory information, utilizing glutamate for maintenance of baseline cardiorespiratory parameters and initiation of reflexes, with astrocytes in the nTS contributing through various mechanisms such as gliotransmission and glutamate regulation. Recent evidence emphasizes the significance of astrocytes in the nTS and their impact on autonomic and cardiorespiratory processes under normal and hypoxic conditions.

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