相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Metformin and silymarin afford protection in cyclosporine A induced hepatorenal toxicity in rat by modulating redox status and inflammation
Sneha Vangaveti et al.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)
Mortality risk with preadmission metformin use in patients with COVID-19 and diabetes: A meta-analysis
Chia Siang Kow et al.
JOURNAL OF MEDICAL VIROLOGY (2021)
Reports of Lactic Acidosis Attributed to Metformin, 2015-2018
James H. Flory et al.
DIABETES CARE (2020)
Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis
Pan Luo et al.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2020)
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
Leena P. Bharath et al.
CELL METABOLISM (2020)
Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase α2
Junling Gao et al.
REDOX BIOLOGY (2020)
Metformin loaded phosphatidylserine nanoliposomes improve memory deficit and reduce neuroinflammation in streptozotocin-induced Alzheimer's disease model
Partow Mirzaee Saffari et al.
LIFE SCIENCES (2020)
High fat-induced inflammation in vascular endothelium can be improved by Abelmoschus esculentus and metformin via increasing the expressions of miR-146a and miR-155
Luoning Gou et al.
NUTRITION & METABOLISM (2020)
Neuroprotective potential of antihyperglycemic drug metformin in streptozocin-induced rat model of sporadic Alzheimer's disease
Vladimirs Pilipenko et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2020)
Significance of Metformin Use in Diabetic Kidney Disease
Daiji Kawanami et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Association between metformin and neurodegenerative diseases of observational studies: systematic review and meta-analysis
Fan Ping et al.
BMJ OPEN DIABETES RESEARCH & CARE (2020)
Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation
Yili Fang et al.
CELL DEATH DISCOVERY (2020)
Metformin and cancer immunity
Ruixia Ma et al.
ACTA PHARMACOLOGICA SINICA (2020)
Relationships between memory decline and the use of metformin or DPP4 inhibitors in people with type 2 diabetes with normal cognition or Alzheimer's disease, and the role APOE carrier status
Che-Yuan Wu et al.
ALZHEIMERS & DEMENTIA (2020)
Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial
Justin C. Brown et al.
CANCER PREVENTION RESEARCH (2020)
Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes
Xu Cheng et al.
CELL METABOLISM (2020)
Metformin suppresses inflammation and apoptosis of myocardiocytes by inhibiting autophagy in a model of ischemia-reperfusion injury
Kai-yu Huang et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)
Renal dysfunction in a mouse model of GDM is prevented by metformin through MAPKs
Zhengfei Liu et al.
MOLECULAR MEDICINE REPORTS (2019)
Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer's disease: Pooled analysis from 5 cohorts
Galit Weinstein et al.
PLOS ONE (2019)
A novel therapeutic approach to colorectal cancer in diabetes: role of metformin and rapamycin
Alice Gerges Geagea et al.
Oncotarget (2019)
Hyperglycemia induces NF-κB activation and MCP-1 expression via downregulating GLP-1R expression in rat mesangial cells: inhibition by metformin
Zhanfang Kang et al.
CELL BIOLOGY INTERNATIONAL (2019)
Metformin inhibits PPARδ agonist-mediated tumor growth by reducing Glut1 and SLC1A5 expressions of cancer cells
Jiajun Ding et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2019)
Metformin inhibits Aβ25-35-induced apoptotic cell death in SH-SY5Y cells
Li-Xia Li et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2019)
Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2
Rui Tian et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)
Metformin modulates cardiac endothelial dysfunction, oxidative stress and inflammation in irradiated rats: A new perspective of an antidiabetic drug
Heba M. Karam et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2019)
Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer's Disease
Susan A. Farr et al.
JOURNAL OF ALZHEIMERS DISEASE (2019)
Possible involvement of metformin in downregulation of neuroinflammation and associated behavioural changes in mice
Jayesh Mudgal et al.
INFLAMMOPHARMACOLOGY (2019)
Metformin attenuates diabetes-induced tau hyperphosphorylation in vitro and in vivo by enhancing autophagic clearance
Jin-Liang Chen et al.
EXPERIMENTAL NEUROLOGY (2019)
Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish
Sofia de Oliveira et al.
JOURNAL OF HEPATOLOGY (2019)
The effect of metformin on biomarkers and survivals for breast cancer- a systematic review and meta-analysis of randomized clinical trials
Zhi-Jiang Zhang et al.
PHARMACOLOGICAL RESEARCH (2019)
Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice
Zhenri Ou et al.
BRAIN BEHAVIOR AND IMMUNITY (2018)
Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-kappa B and MAPK signaling pathway
Li Tao et al.
BRAIN RESEARCH BULLETIN (2018)
Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or 4
Jean-Daniel Lalau et al.
DIABETES CARE (2018)
Metformin attenuates folic-acid induced renal fibrosis in mice
Hao Yi et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2018)
An Inflammation-Centric View of Neurological Disease: Beyond the Neuron
Stephen D. Skaper et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2018)
Metabolic Effects of Metformin in the Failing Heart
Aleksandra Dziubak et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Protective effects of metformin, statins and anti-inflammatory drugs on head and neck cancer: A systematic review
Constanza Saka Herran et al.
ORAL ONCOLOGY (2018)
Divergent Effects of Metformin on an Inflammatory Model of Parkinson's Disease
Khadija Tayara et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2018)
Metformin Attenuates Myocardium Dicarbonyl Stress Induced by Chronic Hypertriglyceridemia
H. Malinska et al.
PHYSIOLOGICAL RESEARCH (2018)
Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission
Qilong Wang et al.
DIABETES (2017)
Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK
Gang Liu et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2017)
Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line
Zhihui Xiao et al.
MEDIATORS OF INFLAMMATION (2017)
DIABETES MELLITUS Complex interplay between metformin, AKI and lactic acidosis
Connie M. Rhee et al.
NATURE REVIEWS NEPHROLOGY (2017)
Metformin Attenuates Neurological Deficit after Intracerebral Hemorrhage by Inhibiting Apoptosis, Oxidative Stress and Neuroinflammation in Rats
Boxiang Qi et al.
NEUROCHEMICAL RESEARCH (2017)
Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease
Nikita Katila et al.
NEUROPHARMACOLOGY (2017)
Effects of metformin exposure on neurodegenerative diseases in elderly patients with type 2 diabetes mellitus
Yi-Chun Kuan et al.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2017)
Antiaging Effect of Metformin on Brain in Naturally Aged and Accelerated Senescence Model of Rat
Geetika Garg et al.
REJUVENATION RESEARCH (2017)
Risk of acute kidney injury and survival in patients treated with Metformin: an observational cohort study
Samira Bell et al.
BMC NEPHROLOGY (2017)
Metformin ameliorates sepsis-induced brain injury by inhibiting apoptosis, oxidative stress and neuroinflammation via the PI3K/Akt signaling pathway
Guangming Tang et al.
ONCOTARGET (2017)
Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection
Hojin Kang et al.
ONCOTARGET (2017)
MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway
Mao Luo et al.
SCIENTIFIC REPORTS (2017)
Risks of Metformin in Type 2 Diabetes and Chronic Kidney Disease: Lessons Learned from Taiwanese Data
Connie M. Rhee et al.
NEPHRON (2017)
Two-year follow-up of 4 months metformin treatment vs. placebo in ST-elevation myocardial infarction: data from the GIPS-III RCT
Minke H. T. Hartman et al.
CLINICAL RESEARCH IN CARDIOLOGY (2017)
Potential of Metformin to Improve Cardiac Risk in Postpartum Women with Gestational Diabetes
Oscar A. Viteri et al.
FRONTIERS IN MEDICINE (2017)
Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease
Julia C. Fitzgerald et al.
BRAIN (2017)
Extending Metformin Use in Diabetic Kidney Disease: A Pharmacokinetic Study in Stage 4 Diabetic Nephropathy
Ajith Munasinghe Dissanayake et al.
KIDNEY INTERNATIONAL REPORTS (2017)
Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study
Aaron M. Koenig et al.
ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2017)
Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates
Pasquale Picone et al.
AGING-US (2016)
Combination of metformin and 5-aminosalicylic acid cooperates to decrease proliferation and induce apoptosis in colorectal cancer cell lines
Mona M. Saber et al.
BMC CANCER (2016)
Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice
Wilma Helena Oliveira et al.
BRAIN RESEARCH (2016)
Metformin Activates AMPK through the Lysosomal Pathway
Chen-Song Zhang et al.
CELL METABOLISM (2016)
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
Amy R. Cameron et al.
CIRCULATION RESEARCH (2016)
Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein
Hana Malinska et al.
PLOS ONE (2016)
Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system
Afrah A. K. Ismaiel et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)
Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 & 2 and AMP-activated Protein Kinase in the Kidney
Michael Christensen et al.
SCIENTIFIC REPORTS (2016)
Metformin Alleviated Aβ-Induced Apoptosis via the Suppression of JNK MAPK Signaling Pathway in Cultured Hippocampal Neurons
Bin Chen et al.
BIOMED RESEARCH INTERNATIONAL (2016)
Metformin attenuated the inflammation after renal ischemia/reperfusion and suppressed apoptosis of renal tubular epithelial cell in rats
Zhi-shun Wang et al.
ACTA CIRURGICA BRASILEIRA (2015)
Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect
Pasquale Picone et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)
Metformin Action: Concentrations Matter
Ling He et al.
CELL METABOLISM (2015)
Metformin affects the features of a human hepatocellular cell line (HepG2) by regulating macrophage polarization in a co-culture microenviroment
Miaojiao Chen et al.
DIABETES-METABOLISM RESEARCH AND REVIEWS (2015)
Metformin prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction
Rita C. Cavaglieri et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2015)
Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction
Zaid Al-Wahab et al.
ONCOTARGET (2015)
Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect
Yoshifumi Saisho
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2015)
Metformin Inhibits Monocyte-to-Macrophage Differentiation via AMPK-Mediated Inhibition of STAT3 Activation: Potential Role in Atherosclerosis
Sathish Babu Vasamsetti et al.
DIABETES (2015)
Chronic Metformin Preconditioning Provides Neuroprotection via Suppression of NF-kappa B-Mediated Inflammatory Pathway in Rats with Permanent Cerebral Ischemia
Xi-Chen Zhu et al.
MOLECULAR NEUROBIOLOGY (2015)
Metformin: From Mechanisms of Action to Therapies
Marc Foretz et al.
CELL METABOLISM (2014)
Incidence of Bladder Cancer in Patients With Type 2 Diabetes Treated With Metformin or Sulfonylureas
Ronac Mamtani et al.
DIABETES CARE (2014)
Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction
Hamid Soraya et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2014)
Effect of Metformin on Left Ventricular Function After Acute Myocardial Infarction in Patients Without Diabetes The GIPS-III Randomized Clinical Trial
Chris P. H. Lexis et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)
Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer
Seong-Joon Koh et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014)
Modulation by metformin of molecular and histopathological alterations in the lung of cigarette smoke-exposed mice
Alberto Izzotti et al.
CANCER MEDICINE (2014)
Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial
David Preiss et al.
LANCET DIABETES & ENDOCRINOLOGY (2014)
Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
Filipe Cabreiro et al.
CELL (2013)
Metformin, Microbes, and Aging
Gilles Storelli et al.
CELL METABOLISM (2013)
Effects of Metformin Versus Glipizide on Cardiovascular Outcomes in Patients With Type 2 Diabetes and Coronary Artery Disease
Jie Hong et al.
DIABETES CARE (2013)
Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin
Eileen M. Moore et al.
DIABETES CARE (2013)
Metformin decreases high-fat diet-induced renal injury by regulating the expression of adipokines and the renal AMP-activated protein kinase/acetyl-CoA carboxylase pathway in mice
Dal Kim et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
Morgan D. Fullerton et al.
NATURE MEDICINE (2013)
Metformin improves healthspan and lifespan in mice
Alejandro Martin-Montalvo et al.
NATURE COMMUNICATIONS (2013)
Metformin inhibits inflammatory response via AMPK-PTEN pathway in vascular smooth muscle cells
Sun Ae Kim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study
Patrick Imfeld et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2012)
Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort
Mark L. Wahlqvist et al.
PARKINSONISM & RELATED DISORDERS (2012)
Metformin restores endothelial function in aorta of diabetic rats
Cristina M. Sena et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Insulin and metformin may prevent renal injury in young type 2 diabetic Goto-Kakizaki rats
Teresa M. Louro et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
Metformin Treatment Exerts Antiinvasive and Antimetastatic Effects in Human Endometrial Carcinoma Cells
Bee K. Tan et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)
Statins, inflammation and kidney disease
Vera Krane et al.
NATURE REVIEWS NEPHROLOGY (2011)
Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes
Amit Gupta et al.
NEUROPHARMACOLOGY (2011)
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
Eva Kickstein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Inflammation Bares a Dark Side
Jennifer Couzin-Frankel
SCIENCE (2010)
Long-term Effects of Metformin on Metabolism and Microvascular and Macrovascular Disease in Patients With Type 2 Diabetes Mellitus
Adriaan Kooy et al.
ARCHIVES OF INTERNAL MEDICINE (2009)
Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription
Yaomin Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
10-year follow-up of intensive glucose control in type 2 diabetes
Rury R. Holman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries - A randomized, double-blind, placebo-controlled study
Sachin Jadhav et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)
Metformin inhibits cytokine-induced nuclear factor kappa B activation via AMP-activated protein kinase activation in vascular endothelial cells
Yoshiyuki Hattori et al.
HYPERTENSION (2006)
Inflammatory exposure and historical changes in human life-spans
CE Finch et al.
SCIENCE (2004)
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
WC Knowler et al.
NEW ENGLAND JOURNAL OF MEDICINE (2002)
Role of AMP-activated protein kinase in mechanism of metformin action
GC Zhou et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
分享论文
