期刊
FRONTIERS IN PHARMACOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.632662
关键词
neuroserpin; cobalt chloride (CoCl2); hypoxia; protective; oxidative stress
资金
- Science and Technology Commission of Shanghai Municipality [13441902600]
- Clinical Medical Research Grant of Chinese medical Association [09010180173]
Neuroserpin deficiency in zebrafish exposed to CoCl2 induced hypoxic injury showed more development defects, neuronal loss, and vascular malformation compared to wide-type, indicating a protective role of neuroserpin against CoCl2 induced hypoxic injury by alleviating oxidative stress.
Protective strategy against hypoxic-ischemic (H/I) induced injury has been intensively discussed. Neuroserpin, an inhibitor for tissue plasminogen activator (tPA), has been proved a vital neuroprotective agent in cerebral ischemia mouse model and oxygen-glucose deprivation and reoxygenation (OGD/R) cell model. Neuroserpin is a promising therapeutic hint for neonatal hypoxic-ischemia injury. Here, we established a neuroserpin deficient zebrafish to study its role in CoCl2 chemically induced hypoxic injury. CoCl2 exposure was beginning at the embryonic stage. Development defects, neuronal loss, and vascular malformation was assessed by imaging microscopy. Neuroserpin deficient zebrafish showed more development defects, neuronal loss and vascular malformation compared to wide-type. Apoptosis and oxidative stress were evaluated to further identify the possible mechanisms. These findings indicate that neuroserpin could protective against CoCl2 induced hypoxic injury by alleviating oxidative stress.
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