期刊
FRONTIERS IN NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2021.618435
关键词
quantitative susceptibility mapping; brain; iron; Alzheimer' s disease; Parkinson' s disease; neurodegenerative diseases
资金
- National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship [1105825]
- NHMRC L3 Investigator Grant [1194028, 1196508]
- Australian National Health and Medical Research Council [1177370]
- University of Melbourne Dame Kate Campbell Fellowship
- Australian Government NCRIS program
- National Imaging Facility
- National Health and Medical Research Council of Australia [1194028, 1196508] Funding Source: NHMRC
Iron has been increasingly implicated in the pathology of neurodegenerative diseases. The development of QSM technique allows for more comprehensive investigation of iron distribution in the brain. Existing studies have shown increased magnetic susceptibility in brain regions associated with different neurodegenerative disorders, indicating potential for QSM as a promising tool in investigating neurodegeneration.
Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In the past decade, development of the new magnetic resonance imaging technique, quantitative susceptibility mapping (QSM), has enabled for the more comprehensive investigation of iron distribution in the brain. The aim of this systematic review was to provide a synthesis of the findings from existing QSM studies in neurodegenerative diseases. We identified 80 records by searching MEDLINE, Embase, Scopus, and PsycInfo databases. The disorders investigated in these studies included Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Wilson's disease, Huntington's disease, Friedreich's ataxia, spinocerebellar ataxia, Fabry disease, myotonic dystrophy, pantothenate-kinase-associated neurodegeneration, and mitochondrial membrane protein-associated neurodegeneration. As a general pattern, QSM revealed increased magnetic susceptibility (suggestive of increased iron content) in the brain regions associated with the pathology of each disorder, such as the amygdala and caudate nucleus in Alzheimer's disease, the substantia nigra in Parkinson's disease, motor cortex in amyotrophic lateral sclerosis, basal ganglia in Huntington's disease, and cerebellar dentate nucleus in Friedreich's ataxia. Furthermore, the increased magnetic susceptibility correlated with disease duration and severity of clinical features in some disorders. Although the number of studies is still limited in most of the neurodegenerative diseases, the existing evidence suggests that QSM can be a promising tool in the investigation of neurodegeneration.
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