4.6 Review

Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing

期刊

MICROMACHINES
卷 12, 期 2, 页码 -

出版社

MDPI
DOI: 10.3390/mi12020139

关键词

tissue chips; microphysiological systems; microfluidics; organ-on-a-chip; tissue-on-a-chip; body-on-a-chip

资金

  1. NIH T32 grant [DK116672, EB023872]
  2. NIH F31 grant [DK127809]
  3. NIH R01 grant [HL148462]

向作者/读者索取更多资源

This review discusses tissue chips and microphysiological systems, highlighting their basic definitions, major organs/tissues, critical parameters, and microfluidic approaches. It addresses current shortcomings and future directions of these technologies.
Tissue chips (TCs) and microphysiological systems (MPSs) that incorporate human cells are novel platforms to model disease and screen drugs and provide an alternative to traditional animal studies. This review highlights the basic definitions of TCs and MPSs, examines four major organs/tissues, identifies critical parameters for organization and function (tissue organization, blood flow, and physical stresses), reviews current microfluidic approaches to recreate tissues, and discusses current shortcomings and future directions for the development and application of these technologies. The organs emphasized are those involved in the metabolism or excretion of drugs (hepatic and renal systems) and organs sensitive to drug toxicity (cardiovascular system). This article examines the microfluidic/microfabrication approaches for each organ individually and identifies specific examples of TCs. This review will provide an excellent starting point for understanding, designing, and constructing novel TCs for possible integration within MPS.

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