期刊
FRONTIERS IN PLANT SCIENCE
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpls.2021.629013
关键词
Arabidopsis thaliana; co-expression; Cucumis sativus; iron; molybdenum; network topology; protein– protein interaction; plant nutrition
资金
- Italian National Ministry of Research (MIUR) [PRIN 2017-2017FBS8YN_00]
- Department of Life Sciences and Systems Biology, University of Turin
- Fondo per il Finanziamento delle Attivita Base di Ricerca 2017
Network analysis, based on graph theory, is a systems biology approach used to study protein-protein interactions and co-expression networks. This method can assist in identifying novel players involved in multiple homeostatic interactions.
Network analysis is a systems biology-oriented approach based on graph theory that has been recently adopted in various fields of life sciences. Starting from mitochondrial proteomes purified from roots of Cucumis sativus plants grown under single or combined iron (Fe) and molybdenum (Mo) starvation, we reconstructed and analyzed at the topological level the protein-protein interaction (PPI) and co-expression networks. Besides formate dehydrogenase (FDH), already known to be involved in Fe and Mo nutrition, other potential mitochondrial hubs of Fe and Mo homeostasis could be identified, such as the voltage-dependent anion channel VDAC4, the beta-cyanoalanine synthase/cysteine synthase CYSC1, the aldehyde dehydrogenase ALDH2B7, and the fumaryl acetoacetate hydrolase. Network topological analysis, applied to plant proteomes profiled in different single or combined nutritional conditions, can therefore assist in identifying novel players involved in multiple homeostatic interactions.
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