期刊
FRONTIERS IN MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.615618
关键词
synergy; antagonism; suppression; biocides; antibiotics; pseudomonas aeruginosa; CTAB (cetyltrimethylammonium bromide); Povidone-iodine (PVP-I)
类别
资金
- Joint Programming Initiative on Antimicrobial Resistance (JPI-EC-AMR)
- BEAT-AMR project - BMBF [01KI1710]
- BAM
The study shows that the combination use of antibiotics with biocides or antiseptics can have physiological combination effects on the pathogen P. aeruginosa, with synergistic and antagonistic effects observed. These effects have implications for the efficacy of both types of substances and may lead to the selective emergence of antimicrobial resistant strains in clinical applications.
Antimicrobials can exert specific physiological effects when used in combination that are different from those when applied alone. While combination effects have been extensively mapped for antibiotic-antibiotic combinations, the combination effects of antibiotics with antimicrobials used as biocides or antiseptics have not been systematically investigated. Here, we investigated the effects of combinations of antibiotics (meropenem, gentamicin, and ciprofloxacin) and substances used as biocides or antiseptics [octenidine, benzalkonium chloride, cetrimonium bromide, chlorhexidine, Povidone-iodine, silver nitrate (AgNO3), and Ag-nanoparticles] on the planktonic growth rate of Pseudomonas aeruginosa. Combination effects were investigated in growth experiments in microtiter plates at different concentrations and the Bliss interaction scores were calculated. Among the 21 screened combinations, we find prevalent combination effects with synergy occurring six times and antagonism occurring 10 times. The effects are specific to the antibiotic-biocide combination with meropenem showing a tendency for antagonism with biocides (6 of 7), while gentamicin has a tendency for synergy (5 of 7). In conclusion, antibiotics and biocides or antiseptics exert physiological combination effects on the pathogen P. aeruginosa. These effects have consequences for the efficacy of both types of substances and potentially for the selection of antimicrobial resistant strains in clinical applications with combined exposure (e.g., wound care and coated biomaterials).
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