期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2021.563085
关键词
COVID-19; cytokines; IL-6; IL-8; ACE2
资金
- British Heart Foundation [PG/14/27/30679]
- Dunhill Medical Trust [R368/0714]
- Welcome Trust [093080/Z/10/Z]
- EPSRC [EP/T003189/1]
- Community Jameel Imperial College COVID-19 Excellence Fund [G26290]
- UK MRC [MR/T010371/1]
COVID-19, caused by a novel coronavirus, has rapidly spread to an epidemic scale, declared a Public Health Emergency of International Concern by WHO. Research progress on molecular features and immunopathogenesis provides a reference for further prevention and treatment strategies for SARS-CoV-2 infection.
In late December 2019, a vtiral pneumonia with an unknown agent was reported in Wuhan, China. A novel coronavirus was identified as the causative agent. Because of the human-to-human transmission and rapid spread; coronavirus disease 2019 (COVID-19) has rapidly increased to an epidemic scale and poses a severe threat to human health; it has been declared a public health emergency of international concern (PHEIC) by the World Health Organization (WHO). This review aims to summarize the recent research progress of COVID-19 molecular features and immunopathogenesis to provide a reference for further research in prevention and treatment of SARS coronavirus2 (SARS-CoV-2) infection based on the knowledge from researches on SARS-CoV and Middle East respiratory syndrome-related coronavirus (MERS-CoV).
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