期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2021.579323
关键词
intestinal flora; bone homeostasis; bone formation; bone resorption; probiotics; prebiotics
资金
- National Natural Science Foundation of China [81802164]
- Henan Key R&D Promotion Project [22170108]
- Medical Scientific and Technological Research Project of Henan Province [SBGJ2018029]
- Youth Innovation Fund Project of The First Affiliated Hospital of Zhengzhou University [YNQN2017040]
The intestinal flora, considered as the second gene pool of the human body, has a complex symbiotic relationship with the host and can regulate bone homeostasis through the host immune, metabolic, and endocrine systems. Changing the composition and function of the intestinal flora using probiotics, prebiotics, and fecal microbiota transplantation is being explored as a potential novel approach for regulating bone homeostasis.
Intestinal flora located within the intestinal tract comprises a large number of cells, which are referred to as the second gene pool of the human body and form a complex symbiotic relationship with the host. The knowledge of the complex interaction between the intestinal flora and various life activities of the host is a novel and rapidly expanding field. Recently, many studies are being conducted on the relationship between the intestinal flora and bone homeostasis and indicate that the intestinal flora can regulate bone homeostasis via the host immune, metabolic, and endocrine systems. What's more, based on several clinical and preclinical pieces of evidence, changing the composition and function of the host intestinal flora through the application of probiotics, prebiotics, and fecal microbiota transplantation is being considered to be a potential novel target for the regulation of bone homeostasis. Here, we searched relevant literature and reviewed the role of the intestinal flora in the regulation of bone homeostasis and its modulating interventions.
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