期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2020.585917
关键词
Porphyromonas gingivalis; outer membrane vesicles; virulence factors; periodontal disease; systemic diseases
资金
- National Natural Science Foundation of China [81870771, 81800975]
- China Postdoctoral Science Foundation [2018M640269, 2019T120224]
Periodontal disease is a chronic infectious disease associated with various systemic diseases, with P. gingivalis as the key pathogen producing OMVs that play an important role in disease pathogenesis.
Periodontal disease is a chronic infectious disease associated with a variety of bacteria, which can cause damage to the periodontal support structure and affect a variety of systemic system diseases such as cancer, cardiovascular disease, diabetes, rheumatoid arthritis, non-alcoholic fatty liver, and Alzheimer's disease. Porphyromonas gingivalis (P. gingivalis) is the most important pathogenic bacteria for periodontal disease. It can produce outer membrane vesicles (OMVs) and release them into the environment, playing an important role in its pathogenesis. This article focuses on P. gingivalis OMVs, reviews its production and regulation, virulence components, mode of action and related diseases, with a view to providing new ideas for the prevention and treatment of diseases related to P. gingivalis infections.
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