期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2020.593823
关键词
effector-triggered immunity; effector-mediated immunity; Legionella pneumophila; innate immunity; macrophage
资金
- NIH NIGMS COBRE Research Project Grant [P20GM130448]
- NIH Kansas-INBRE Postdoctoral Fellowship [P20GM103418]
- U.S. Department of Agriculture Research Service project [3020-43440-001-00D]
- Kansas State University
The article discusses the immune responses mediated by effector proteins in Gram-negative bacterial pathogens and the potential future of developing new drugs using effector proteins.
Many Gram-negative bacterial pathogens employ translocated virulence factors, termed effector proteins, to facilitate their parasitism of host cells and evade host anti-microbial defenses. However, eukaryotes have evolved to detect effector-mediated virulence strategies through a phenomenon termed effector-triggered immunity (ETI). Although ETI was discovered in plants, a growing body of literature demonstrates that metazoans also utilize effector-mediated immunity to detect and clear bacterial pathogens. This mini review is focused on mechanisms of effector-mediated immune responses by the accidental human pathogen Legionella pneumophila. We highlight recent advancements in the field and discuss the future prospects of harnessing effectors for the development of novel therapeutics, a critical need due to the prevalence and rapid spread of antibiotic resistance.
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