期刊
BIOMED RESEARCH INTERNATIONAL
卷 2021, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2021/6663003
关键词
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资金
- Fundamental Research Funds for the Central Universities of the Central South University [2018zzts930]
- National Science Foundation of China [81170823]
- Philosophy and Social Science Foundation of Hunan Province [18YBA325]
- Project of Hunan Provincial Department of Education [160546]
- Hunan Provincial Health and Health Commission Scientific Research Fund Project [C2019055]
- Hunan Provincial Department of Finance 2017 Project (Xiangcai Finance Agency) [[2017] 61]
- Ningxia Hui Autonomous Region Philosophy and Social Science Planning Year Project [19NXAGL01]
- Hunan Province's 225 Project Training Discipline Leader Project for High-Level Health Professionals
- Special Project of Central Guidance for Local Science and Technology Development [2020YDDF0043]
This study found that MSC therapy is the most effective in relieving pain caused by osteoarthritis, outperforming PRP, HA, and GCs. MSCs also showed advantages in improving OA symptoms and are well tolerated by patients in long-term treatment compared to placebo.
Objective. Osteoarthritis (OA) is the most common degenerative joint disease, causing joint pain, stiffness, and even disability. Guidelines recommend intra-articular injections as an alternative treatment to relieve OA symptoms for patients who demonstrate poor tolerability or compliance to oral administration of drugs. Mesenchymal stem cells (MSCs) are a potential treatment for of OA. We conducted this network meta-analysis to comprehensively compare the efficacy and safety between hyaluronic acid (HA), corticosteroids (GCs), platelet-rich plasma (PRP), and MSCs. Design. Systematic review and Bayesian network meta-analysis. Data Sources. Relevant studies, published from January 2000 to January 2020, in the PubMed, Cochrane library, EMBASE, and CKNI databases. Methods. Bayesian network and conventional meta-analyses were conducted. Pain relief, functional improvement, improvement in joint stiffness, and risk of adverse effects (AEs) were assessed. Results. Twenty-five articles with 4642 patients were included. Overall, MSC therapy was the most effective treatment for pain relief (standardized mean difference compared with placebo=3.61, 95% CI [1.87 to 5.35]). Both MSC and PRP therapies improved every symptom of OA effectively and have an advantage over HA and GCs which are recommended by guidelines. MSCs, PRP, HA, and GCs are tolerated well for patients in long-term treatment of OA compared with placebo. Conclusions. The results show that MSCs relieve pain, stiffness, and dysfunction due to OA better than PRP, HA, and GCs and are not statistically correlated with greater safety concerns. More high-quality trials are needed to reconfirm the findings of this study, however, standardization of preparation of MSCs and PRP should be investigated in the future.
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