Copper-Catalyzed Tandem Cross-Coupling/Annulation of Phenols with Ketoximes through Dual C-H Functionalization: Synthesis of Substituted 2-Aryl-1H-indoles

A copper-catalyzed cascade synthesis of substituted 2-aryl-1H-indoles from phenols and oximes is developed. This reaction involves dual C-H bond cleavage of phenols and cyclization with oximes and proceeds smoothly under mild conditions without any additives.

Automated summary

A copper-catalyzed cascade synthesis of substituted 2-aryl-1H-indoles from phenols and oximes is developed, involving dual C-H bond cleavage of phenols and cyclization with oximes. The reaction proceeds smoothly under mild conditions without any additives.