Botulinum Neurotoxin Injections in Childhood Opisthotonus

Opisthotonus refers to abnormal axial extension and arching of the trunk produced by excessive contractions of the paraspinal muscles. In childhood, the abnormal posture is most often related to dystonia in the setting of hypoxic injury or a number of other acquired and genetic etiologies. The condition is often painful, interferes with ambulation and quality of life, and is challenging to treat. Therapeutic options include oral benzodiazepines, oral and intrathecal baclofen, botulinum neurotoxin injections, and deep brain stimulation. Management of opisthotonus within the pediatric population has not been systematically reviewed. Here, we describe a series of seven children who presented to our institution with opisthotonus in whom symptom relief was achieved following administration of botulinum neurotoxin injections.

Automated summary

Opisthotonus is a condition characterized by abnormal trunk extension and arching due to excessive contractions of the paraspinal muscles. It is most commonly seen in children with dystonia secondary to hypoxic injury or other acquired and genetic causes. Treatment options include oral medications, muscle injections, and deep brain stimulation, although management in the pediatric population has not been systematically reviewed.