期刊
ENVIRONMENTAL POLLUTION
卷 210, 期 -, 页码 48-56出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2015.12.001
关键词
Microcystin-LR; Lung; Mitochondria; mtDNA
资金
- National Natural Science Foundation of China [21107048, 81270152]
- Open Foundation of the State Key Laboratory of Pharmaceutical Biotechnology [KF-GN-201201]
- Innovative Engineering Training of Jiangsu Province [CXLX12-0059]
Microcystin-LR (MC-LR), an important variant of cyanotoxin family, was frequently encountered in the contaminated aquatic environment and taken as a potent hepatotoxin. However, a little was known on the association between the long-term MC-LR exposure and lung damage. In this study, we investigated the changes of the pulmonary histopathology, mitochondrial DNA (mtDNA) integrity and the expression of mtDNA encoded genes in the mice with chronic exposed to MC-LR at different concentrations (1, 5,10, 20 and 40 mu g/L) for 12 months. Our results showed that the long-term and persistent exposure to MC-LR disturbed the balance of redox system, influenced mtDNA stability, changed the expression of mitochondrial genes in the lung cells. Notably, MC-LR exposure influenced the level of inflammatory cytokines and resulted in thickening of the alveolar septa. In conclusion, chronic exposure to MC-LR affected mtDNA maintenance, and caused lung impairment in mice. (C) 2015 Elsevier Ltd. All rights reserved.
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