期刊
POLYMERS
卷 13, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/polym13050775
关键词
polymer extrusion; electrophoretic deposition; nerve tissue engineering; hydrogels; implants
资金
- NATIONAL SCIENCE CENTRE, POLAND [2017/26/D/ST8/00196]
- NATIONAL CENTRE FOR RESEARCH AND DEVELOPMENT, POLAND [LIDER/18/0116/L-10/18/NCBR/2019]
A new technology combining polymer extrusion and electrophoretic deposition has been developed to fabricate hybrid implants with a two-layer structure for customized nerve tissue engineering applications. The implants can be functionalized with mechanical or biological cues to enhance their performance.
Major efforts for the advancement of tubular-shaped implant fabrication focused recently on the development of 3D printing methods that can enable the fabrication of complete devices in a single printing process. However, the main limitation of these solutions is the use of non-biocompatible polymers. Therefore, a new technology for obtaining hybrid implants that employ polymer extrusion and electrophoretic deposition is applied. The fabricated structures are made of two layers: polycaprolactone skeleton and chitosan-hydroxyapatite electrodeposit. Both of them can be functionalized by incorporation of mechanical or biological cues that favor ingrowth, guidance, and correct targeting of axons. The electrodeposition process is conducted at different voltages in order to determine the influence of this process on the structural, chemical, and mechanical properties of implants. In addition, changes in mechanical properties of implants during their incubation in phosphate-buffered solution (pH 7.4) at 37 degrees C up to 28 days are examined. The presented technology, being low-cost and relatively simple, shall find a broad scope of applications in customized nerve tissue engineering.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据