4.3 Editorial Material

Genetic risks and association with severe COVID-19 among global populations

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Article Multidisciplinary Sciences

Genetic mechanisms of critical illness in COVID-19

Erola Pairo-Castineira et al.

Summary: In critically ill patients with COVID-19, host genetic variants associated with antiviral defense mechanisms and inflammatory organ damage were identified through a genome-wide association study. These genetic signals provide potential targets for therapeutic development and repurposing of existing drugs. Large-scale randomized clinical trials will be essential to confirm the effectiveness of targeted treatment strategies.

NATURE (2021)

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Genomewide Association Study of Severe Covid-19 with Respiratory Failure

David Ellinghaus et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)