期刊
OPEN BIOLOGY
卷 11, 期 2, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.200360
关键词
basement membrane; mechanics; tissue shape; tissue dynamics; basement membrane dynamics; basement membrane remodelling
资金
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) [NC/T002425/1]
- MRC [MR/L009056/1, MR/T031646/1, MC_U12266B]
- EMBO Young Investigator Programme
- Lister Institute Research Prize
The basement membrane plays a crucial role in tissue development and diseases, with its complex mechanical properties changing through different molecular mechanisms, thereby affecting tissue form and function. Investigating the mechanical properties of the basement membrane is important for disease diagnosis and treatment, as well as the development of better in silico and in vitro models, which can also reduce the use of animals in research.
The basement membrane (BM) is a special type of extracellular matrix that lines the basal side of epithelial and endothelial tissues. Functionally, the BM is important for providing physical and biochemical cues to the overlying cells, sculpting the tissue into its correct size and shape. In this review, we focus on recent studies that have unveiled the complex mechanical properties of the BM. We discuss how these properties can change during development, homeostasis and disease via different molecular mechanisms, and the subsequent impact on tissue form and function in a variety of organisms. We also explore how better characterization of BM mechanics can contribute to disease diagnosis and treatment, as well as development of better in silico and in vitro models that not only impact the fields of tissue engineering and regenerative medicine, but can also reduce the use of animals in research.
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