4.4 Article

Metabolic fingerprints of fear memory consolidation during sleep

期刊

MOLECULAR BRAIN
卷 14, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s13041-021-00733-6

关键词

Fear memory; REM sleep; Non-REM sleep; Dentate gyrus; Hippocampus; Metabolomics; Purine metabolism

资金

  1. World Premier International Research Center Initiative from MEXT, JST CREST [JPMJCR1655]
  2. JSPS KAKENHI [16K18359, 15F15408, 26115502, 25116530, JP16H06280, 19F19310, 20H03552]
  3. Shimadzu Science Foundation
  4. Uehara Memorial Foundation
  5. Takeda Science Foundation
  6. Kanae Foundation
  7. Research Foundation for Opto-Science and Technology
  8. Ichiro Kanehara Foundation
  9. Kato Memorial Bioscience Foundation
  10. Japan Foundation for Applied Enzymology
  11. Senshin Medical Research Foundation
  12. Life Science Foundation of Japan
  13. Brain Science Foundation
  14. Kowa Life Science Foundation
  15. Inamori Research Grants Program
  16. GSK Japan
  17. Grants-in-Aid for Scientific Research [20H03552, 19F19310, 15F15408, 25116530, 16K18359, 26115502] Funding Source: KAKEN

向作者/读者索取更多资源

The study used a metabolomics approach to investigate memory processing during sleep, revealing significant changes in metabolites in the dentate gyrus of mice during sleep-wake states. Changes in purine metabolism were observed during both sleep and contextual fear memory consolidation, suggesting the importance of purine metabolism in fear memory processing.
Metabolites underlying brain function and pathology are not as well understood as genes. Here, we applied a novel metabolomics approach to further understand the mechanisms of memory processing in sleep. As hippocampal dentate gyrus neurons are known to consolidate contextual fear memory, we analyzed real-time changes in metabolites in the dentate gyrus in different sleep-wake states in mice. Throughout the study, we consistently detected more than > 200 metabolites. Metabolite profiles changed dramactically upon sleep-wake state transitions, leading to a clear separation of phenotypes between wakefulness and sleep. By contrast, contextual fear memory consolidation induced less obvious metabolite phenotypes. However, changes in purine metabolites were observed upon both sleep-wake state transitions and contextual fear memory consolidation. Dietary supplementation of certain purine metabolites impaired correlations between conditioned fear responses before and after memory consolidation. These results point toward the importance of purine metabolism in fear memory processing during sleep.

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