期刊
出版社
MDPI
DOI: 10.3390/ijerph18041838
关键词
neurodevelopment; phthalates; sexually dimorphic
资金
- Children's Environmental Health and Disease Prevention Research Centers, National Institute of Environmental Health Sciences [ES022848]
- U.S. Environmental Health Protection Agency [RD83543401]
- Environmental Influences on Child Health Outcomes (ECHO) [OD023272]
- NIH Predoctoral Traineeship in Endocrine, Developmental and Reproductive Toxicology [T32 ES007326]
The study found a gender difference in the association between prenatal phthalate exposure and infants' physical reasoning. For female infants, the exposure was associated with increased viewing time of events they couldn't comprehend, while for male infants, higher exposure was linked to increased viewing time of events they could understand.
The association of prenatal phthalate exposure with physical reasoning was assessed in 159 (78 female; 81 male) 4.5-month-old infants from a prospective cohort. Phthalate metabolites were quantified in urine from 16-18 gestational weeks and a pool of five urines from across pregnancy. Infants' looking times to physically impossible and possible events were recorded via infrared eye-tracking. Infants that recognize that one of the events is impossible will look at that event longer. Associations of phthalate biomarkers with looking time differences (impossible-possible) were adjusted for maternal age, infant sex, and order of event presentation, and effect modification by infant sex was assessed. Each interquartile range (IQR) increase of monoethyl phthalate in the pooled sample was associated with females' increased looking time (beta = 1.0; 95%CI = 0.3, 1.7 s) to the impossible event. However, for males, an IQR increase in monoethyl phthalate at 16-18 weeks (beta = -2.5; 95%CI = -4.4,-0.6 s), the sum of di(isononyl) phthalate metabolites in the pooled sample (beta = -1.0; 95%CI = -1.8, -0.1 s), and the sum of all phthalate metabolites in both samples (beta = -2.3; 95%CI = -4.4, -0.2 s) were associated with increased looking to the possible event, suggesting that higher prenatal phthalate exposure is associated with poorer physical reasoning in male infants.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据