期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 17, 期 7, 页码 2097-2100出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2020.1851129
关键词
EV71 vaccine; hand; foot and mouth disease; encephalitis; protective effect
资金
- Science and Technology Planning Project of Jinan Health and Family Planning Commission [2017-1-42]
The EV71 vaccine significantly reduces the risk of encephalitis in patients with HFMD, but some vaccinated individuals still developed encephalitis, indicating a need for further investigation into the reasons behind this.
In order to analyze the effect of EV71 vaccination on the incidence of encephalitis in patients with HFMD, 292 cases were vaccinated, and 2,486 cases were not vaccinated which were collected in 2018 and 2019. It shows that the incidence rate of encephalitis in vaccinated patients was significantly lower than that in non-vaccinated (P = .028), which suggests that EV71 vaccine has a protective effect on the occurrence of encephalitis. But some EV71 vaccinated patients still developed into encephalitis showed that they had not produced protection or protection was weak against EV71-related encephalitis; the reasons require further investigation.
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