期刊
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
卷 22, 期 8, 页码 844-851出版社
OXFORD UNIV PRESS
DOI: 10.1093/ehjci/jeab042
关键词
magnetic resonance imaging; coronavirus; inflammation; diagnosis
资金
- National Natural Science Foundation of China [81873886, 81873887]
- Shanghai Municipal Commission of Health and Family Planning Excellent Young Talent Program [2017YQ031]
- Shanghai Shenkang Hospital Development Center Clinical Research and Cultivation Project [SHDC12018X21]
- Shanghai Science and Technology Innovation Action Plan, Technology Standard Project [19DZ2203800]
- Shanghai Jiao Tong University School of Medicine Double Hundred Outstanding Person Project [20191904]
- Shanghai Jiao Tong University Medical Cross-Project [YG2017QN44]
In early-stage COVID-19 patients, myocardial edema and functional abnormalities are common findings, while irreversible regional damage such as necrosis may be rare.
Aims In order to determine acute cardiac involvement in patients with COVID-19, we quantitatively evaluated tissue characteristics and mechanics by non-invasive cardiac magnetic resonance (CMR) in a cohort of patients within the first 10 days of the onset of COVID symptoms. Methods and results Twenty-five patients with reverse transcription polymerase chain reaction confirmed COVID-19 and at least one marker of cardiac involvement [cardiac symptoms, abnormal electrocardiograph (ECG), or abnormal cardiac biomarkers] and 25 healthy age- and gender-matched control subjects were recruited to the study. Patients were divided into those with elevated (n = 8) or normal TnI (n = 17). There were significant differences in global longitudinal strain among patients who were positive and negative for hs-TnI, and controls [-12.3 (-13.3, -11.5)%, -13.1 (-14.2, -9.8)%, and -15.7 (-18.3, -12.7)%, P = 0.004]. Native myocardial T1 relaxation times in patients with positive and negative hs-TnI manifestation (1169.8 +/- 12.9 and 1113.2 +/- 31.2 ms) were significantly higher than the normal (1065 +/- 57 ms) subjects, respectively (P < 0.001). The extracellular volume (ECV) of patients who were positive and negative for hs-TnI was higher than that of the normal controls [32 (31, 33)%, 29 (27, 30)%, and 26 (24, 27.5)%, P < 0.001]. In our study, quantitative T2 mapping in patients who were positive and negative for hs-TnI [51 (47.9, 52.8) and 48 (47, 49.4) ms] was significantly higher than the normal [42 (41, 45.2) ms] subjects (P < 0.001). Conclusion In patients with early-stage COVID-19, myocardial oedema, and functional abnormalities are a frequent finding, while irreversible regional injury such as necrosis may be infrequent.
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