期刊
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
卷 47, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dcn.2020.100905
关键词
Early life adversity; Maternal separation; Perineuronal nets; Parvalbumin interneurons; Rats
资金
- Australian Research Council [DP190102975]
- Australian Research Council Discovery Early Career Researcher Award [DE170100392]
- Australian Research Council [DE170100392] Funding Source: Australian Research Council
The early maturation of memory in infants experiencing maternal separation is not due to an accelerated maturation of PNNs or PV-containing cells in either the amygdala or prefrontal cortex, as suggested by experiments with male and female rats.
Early life adversity impacts on a range of emotional, cognitive, and psychological processes. A recent theoretical model suggests that at least some of these effects are due to accelerated maturation of specific physiological systems and/or neural circuits. For example, maternal separation (MS), a model of early life adversity in rodents, accelerates maturation of memory systems, and here we examined its impact on maturation of perineuronal nets (PNNs) and parvalbumin (PV)-containing inhibitory interneurons. PNNs are specialized extracellular matrix structures suggested to be involved in stabilizing long-term memories and in the closure of a sensitive period in memory development. PV-containing inhibitory interneurons are the type of cell that PNNs preferentially sur-round, and are also thought to be involved in memory. In Experiment 1, with male rats, there was an increase in PNNs in both the amygdala and prefrontal cortex with age from infancy to juvenility. Contrary to prediction, MS had no impact on either PNN or PV expression. The same pattern was observed in female rats in Experiment 2. Taken together, these data show that the early maturation of memory in MS infants is not due to an accelerated maturation of PNNs or PV-containing cells in either the amygdala or prefrontal cortex.
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