4.7 Article

A Magnetically Guided Self-Rolled Microrobot for Targeted Drug Delivery, Real-Time X-Ray Imaging, and Microrobot Retrieval

期刊

ADVANCED HEALTHCARE MATERIALS
卷 10, 期 6, 页码 -

出版社

WILEY
DOI: 10.1002/adhm.202001681

关键词

drug delivery; magnetic field control; microrobots; real-time X-ray imaging; shape morphing

资金

  1. Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health and Welfare, Republic of Korea [HI19C0642]
  2. Korea Medical Device Development Fund grant - Korea government (the Ministry of Science and ICT) [202012D19, 202012D20]
  3. Korea Medical Device Development Fund grant - Korea government (the Ministry of Trade, Industry and Energy) [202012D19, 202012D20]
  4. Korea Medical Device Development Fund grant - Korea government (the Ministry of Health Welfare) [202012D19, 202012D20]
  5. Korea Medical Device Development Fund grant - Korea government (the Ministry of Food and Drug Safety) [202012D19, 202012D20]
  6. National Research Foundation of Korea (NRF) - Korea government (MSIT) [2020R1A5A8018367]
  7. National Research Foundation of Korea [2020R1A5A8018367, KMDF_PR_20200901_0128-01] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

This study proposes a novel method utilizing a magnetically guided self-rolled microrobot for targeted drug delivery, combined with real-time X-ray imaging and microrobot retrieval. The microrobot features precise localization and rapid drug release, showing potential for use in precise localized drug delivery systems.
Targeted drug delivery using a microrobot is a promising technique capable of overcoming the limitations of conventional chemotherapy that relies on body circulation. However, most studies of microrobots used for drug delivery have only demonstrated simple mobility rather than precise targeting methods and prove the possibility of biodegradation of implanted microrobots after drug delivery. In this study, magnetically guided self-rolled microrobot that enables autonomous navigation-based targeted drug delivery, real-time X-ray imaging, and microrobot retrieval is proposed. The microrobot, composed of a self-rolled body that is printed using focused light and a surface with magnetic nanoparticles attached, demonstrates the loading of doxorubicin and an X-ray contrast agent for cancer therapy and X-ray imaging. The microrobot is precisely mobilized to the lesion site through automated targeting using magnetic field control of an electromagnetic actuation system under real-time X-ray imaging. The photothermal effect using near-infrared light reveals rapid drug release of the microrobot located at the lesion site. After drug delivery, the microrobot is recovered without potential toxicity by implantation or degradation using a magnetic-field-switchable coiled catheter. This microrobotic approach using automated control method of the therapeutic agents-loaded microrobot has potential use in precise localized drug delivery systems.

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