期刊
SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-021-82311-3
关键词
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资金
- 2017 Monash Malaysia Strategic Large Grant Scheme [LG-2017-01-SCI]
- Tropical Medicine and Biology Platform, Monash University Malaysia
The study found that ethnicity has a significant impact on gut microbiota in a Malaysian community, even after controlling for other factors. Lifestyle, dietary habits, and unknown differences collectively contribute to variation in gut microbiota across ethnicities, making ethnicity a reliable proxy for identifying lifestyle and dietary variations within the community.
No studies have investigated the influence of ethnicity in a multi-ethnic middle-income country with a long-standing history of co-habitation. Stool samples from 214 Malaysian community members (46 Malay, 65 Chinese, 49 Indian, and 54 Jakun) were collected. The gut microbiota of the participants was investigated using 16S amplicon sequencing. Ethnicity exhibited the largest effect size across participants (PERMANOVA Pseudo-F=4.24, R-2=0.06, p=0.001). Notably, the influence of ethnicity on the gut microbiota was retained even after controlling for all demographic, dietary factors and other covariates which were significantly associated with the gut microbiome (PERMANOVA Pseudo-F=1.67, R-2=0.02, p=0.002). Our result suggested that lifestyle, dietary, and uncharacterized differences collectively drive the gut microbiota variation across ethnicity, making ethnicity a reliable proxy for both identified and unidentified lifestyle and dietary variation across ethnic groups from the same community.
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