期刊
SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-021-83323-9
关键词
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资金
- Royal Golden Jubilee (RGJ) Ph.D. program, the Thailand Research Fund [RGJ-PHD/0056/2557]
- Chulalongkorn University under the TSRI fund [CU_FRB640001_01_31_1]
- 90th Anniversary Chulalongkorn University (Ratchadaphiseksomphot Endowment Fund) [GCUGR1125614077D]
- Center of Excellence for Emerging and Re-emerging Infectious Diseases in Animals (CUEIDAs)
- One Health Research Cluster
- Thailand Research Fund (TRF) [RTA6080012]
This study conducted a comprehensive investigation of CPIV-5 in dogs in Thailand, revealing a close relationship between the virus and CPIV-5 isolated from China and Korea. Further surveillance on a larger scale is recommended to determine the dynamics, distribution, and potential zoonotic transmission of CPIV-5.
Parainfluenza virus type 5 (PIV-5) causes respiratory infection in several animal species and humans. Canine parainfluenza virus type 5 (CPIV-5) causes respiratory disease in domestic dogs worldwide. In this study, we conducted a cross-sectional survey of CPIV-5 in dogs with respiratory symptoms from small animal hospitals in Thailand from November 2015 to December 2018. Our results showed that 32 out of 571 nasal swab samples (5.6%) were positive for CPIV-5 by RT-PCR specific to the NP gene. To characterize the viruses, three representative CPIV-5 were subjected to whole genome sequencing, and an additional ten CPIV-5 were subjected to HN, F, SH and V/P gene sequencing. Pairwise sequence comparison and phylogenetic analysis showed that Thai CPIV-5 was closely related to the CPIV-5 isolated from China and Korea. In conclusion, this study constitutes a whole genome characterization of CPIV-5 from dogs in Thailand. The surveillance of CPIV-5 should be further investigated at a larger scale to determine the dynamics, distribution and potential zoonotic transmission of CPIV-5.
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