期刊
NUTRIENTS
卷 13, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/nu13020538
关键词
diet; serum urate; gout; hypertension
资金
- NIH/NHLBI [K23HL135273]
- Rheumatology Research Foundation
- Johns Hopkins Institute for Clinical and Translational Research under the National Center for Advancing Translational Sciences, a component of the National Institutes of Health (NIH) [UL1 TR003098]
- NIH Roadmap for Medical Research
- NIH [P50AR060772]
The study investigated the effects of a dietitian-directed DASH-patterned groceries on serum urate levels in gout patients, showing potential benefits but also noting the vulnerability to strong carryover effects in crossover trials without a washout period. Further research with controlled feeding trials is needed to definitively evaluate the DASH diet as a treatment for gout.
The Dietary Approaches to Stop Hypertension (DASH) diet reduces serum urate (SU); however, the impact of the DASH diet has not been previously evaluated among patients with gout. We conducted a randomized, controlled, crossover pilot study to test the effects of similar to$105/week ($15 /day) of dietitian-directed groceries (DDG), patterned after the DASH diet, on SU, compared with self-directed grocery shopping (SDG). Participants had gout and were not taking urate lowering therapy. Each intervention period lasted 4 weeks; crossover occurred without a washout period. The primary endpoint was SU. Compliance was assessed by end-of-period fasting spot urine potassium and sodium measurements and self-reported consumption of daily servings of fruit and vegetables. We randomized 43 participants (19% women, 49% black, mean age 59 years) with 100% follow-up. Mean baseline SU was 8.1 mg/dL (SD, 0.8). During Period 1, DDG lowered SU by 0.55 mg/dL (95% CI: 0.07, 1.04) compared to SDG by 0.0 mg/dL (95% CI: -0.44, 0.44). However, after crossover (Period 2), the SU difference between groups was the opposite: SDG reduced SU by -0.48 mg/dL (95% CI: -0.98, 0.01) compared to DDG by -0.05 mg/dL (95% CI: -0.48, 0.38; P for interaction by period = 0.11). Nevertheless, DDG improved self-reported intake of fruit and vegetables (3.1 servings/day; 95% CI: 1.5, 4.8) and significantly reduced total spot urine sodium excretion by 22 percentage points (95% CI: -34.0, -8.6). Though relatively small in scale, this pilot study suggests that dietitian-directed, DASH-patterned groceries may lower SU among gout patients not on urate-lowering drugs. However, behavior intervention crossover trials without a washout period are likely vulnerable to strong carryover effects. Definitive evaluation of the DASH diet as a treatment for gout will require a controlled feeding trial, ideally with a parallel-design.
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