4.7 Review

Priming for Life: Early Life Nutrition and the Microbiota-Gut-Brain Axis

期刊

NUTRIENTS
卷 13, 期 2, 页码 -

出版社

MDPI
DOI: 10.3390/nu13020423

关键词

nutrition; early life; microbiota-gut-brain axis; brain development; breast milk; infant formula

资金

  1. European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [754535]
  2. Science Foundation Ireland [SFI/12/RC/2273]
  3. Catedra ORDESA-University of Granada, Spain as part of Special Issue Early Nutrition and Re-programming of Health and Disease

向作者/读者索取更多资源

Microbes colonize the human body at birth and coexist with the host, playing a role in programming important bodily systems during critical developmental windows. Early life nutrition is a key factor in perinatal programming and modulation of offspring microbiota.
Microbes colonize the human body during the first moments of life and coexist with the host throughout the lifespan. Intestinal microbiota and their metabolites aid in the programming of important bodily systems such as the immune and the central nervous system during critical temporal windows of development, with possible structural and functional implications throughout the lifespan. These critical developmental windows perinatally (during the first 1000 days) are susceptible timepoints for insults that can endure long lasting effects on the microbiota-gut-brain axis. Environmental and parental factors like host genetics, mental health, nutrition, delivery and feeding mode, exposure to antibiotics, immune activation and microbiota composition antenatally, are all factors that are able to modulate the microbiota composition of mother and infant and may thus regulate important bodily functions. Among all these factors, early life nutrition plays a pivotal role in perinatal programming and in the modulation of offspring microbiota from birth throughout lifespan. This review aims to present current data on the impact of early life nutrition and microbiota priming of important bodily systems and all the factors influencing the microbial coexistence with the host during early life development.

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