期刊
NUTRIENTS
卷 13, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/nu13030839
关键词
Cone of Pinus densiflora; allergic contact dermatitis; HaCaT; HMC-1; MAPK; NF-κ B; TARC; MCP-1
资金
- National Research Foundation of Korea [2020R1A2C2005836]
- National Research Foundation of Korea [2020R1A2C2005836] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Cone of Pinus densiflora (CP) has various effects such as anti-oxidation, anti-fungal, anti-bacterial, and anti-melanogenic. Studies have shown that CP has anti-inflammatory effects on allergic contact dermatitis both in vitro and in vivo, suggesting its potential as an alternative medicine for chronic skin inflammation.
Cone of Pinus densiflora (CP), or Korean red pinecone, is a cluster of Pinus densiflora fruit. CP has also been verified in several studies to have anti-oxidation, anti-fungal, anti-bacterial, and anti-melanogenic effects. However, anti-inflammatory effects have not yet been confirmed in the inflammatory responses of pinecones to allergic contact dermatitis. The purpose of this study is to prove the anti-inflammatory effect of CP on allergic contact dermatitis (ACD) in vitro and in vivo. CP inhibited the expression of TSLP, TARC, MCP-1, TNF-alpha, and IL-6 in TNF-alpha/IFN-gamma-stimulated HaCaT cells and MCP-1, GM-CSF, TNF-alpha, IL-6, and IL-8 in PMACI (phorbol-12-myristate-13-acetate plus A23187)-stimulated HMC-1 cells. CP inhibited the phosphorylation of mitogen-activated protein kinase (MAPKs), as well as the translocation of NF-kappa B on TNF-alpha/IFN-gamma stimulated in HaCaT cells. In vivo, CP decreased major symptoms of ACD, levels of IL-6 in skin lesion, thickening of the epidermis and dermis, infiltration of eosinophils and mast cells, and the infiltration of CD4(+) T cells and CD8(+) T cells. This result suggests that CP represents a potential alternative medicine to ACD for diseases such as chronic skin inflammation.
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