期刊
NUTRIENTS
卷 13, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/nu13030799
关键词
phenylketonuria; transition to adult care; metabolic control; adherence
资金
- National Funds through FCT-Fundacao para a Ciencia e a Tecnologia, I.P., within CINTESIS, RD Unit [UIDB/4255/2020]
The study focused on reporting the implementation of a phenylketonuria (PKU) transition program and studying the effects of follow-up with an adult team on metabolic control, adherence, and loss of follow-up. The results showed a slight increase in the number of annual blood spots, stable blood Phe levels, and an increase in clinic appointments after the implementation of an adult service. Continuous dietetic care likely contributed to keeping patients in follow-up and committed to treatment.
We aimed to report the implementation of a phenylketonuria (PKU) transition program and study the effects of follow-up with an adult team on metabolic control, adherence, and loss of follow-up. Fifty-five PKU patients were analysed in the study periods (SP): 2 years before (SP1) and after the beginning of adult care (SP2). Retrospective data on metabolic control and number of clinic appointments were collected for each SP, and protein intakes were analysed. In SP2, three patients (6%) were lost to follow-up. There was a small but statistically significant increase in median number of annual blood spots from SP1 to SP2: 11 (7-15) vs. 14 (7-20); p = 0.002. Mean +/- SD of median blood Phe remained stable (525 +/- 248 mu mol/L vs. 552 +/- 225 mu mol/L; p = 0.100); median % of blood Phe < 480 mu mol/L decreased (51 (4-96)% vs. 37 (5-85)%; p = 0.041) and median number of clinic appointments increased from SP1 to SP2: (5 (4-6) vs. 11 (8-13); p < 0.001). No significant differences were found regarding any parameter of protein intake. Our results suggest that the implementation of an adult service was successful as impact on metabolic control was limited and attendance remained high. Continuous dietetic care likely contributed to these results by keeping patients in follow-up and committed to treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据