期刊
NUTRIENTS
卷 13, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/nu13020500
关键词
anorexia nervosa; bulimia nervosa; binge eating; cytokines; gut dysbiosis
资金
- National Institute of Mental Health [MH093311]
- National Institute of Dental and Craniofacial Research [DE014320]
- Medical Marijuana Clinical Outcomes Research Consortium
Alterations in the gut microbiome and immune system may play a role in maintaining and exacerbating eating behavior dysregulation in disorders like anorexia and bulimia, and could potentially serve as biomarkers for increased risk of developing these eating disorders. Research focuses on studying gut dysbiosis, peripheral inflammation, and neuroinflammation in each disorder, as well as exploring data from preclinical rodent models to better understand the biological mechanisms underlying eating disorders. This knowledge is crucial for developing novel and effective treatments for these often difficult-to-treat eating disorders.
There is a growing recognition that both the gut microbiome and the immune system are involved in a number of psychiatric illnesses, including eating disorders. This should come as no surprise, given the important roles of diet composition, eating patterns, and daily caloric intake in modulating both biological systems. Here, we review the evidence that alterations in the gut microbiome and immune system may serve not only to maintain and exacerbate dysregulated eating behavior, characterized by caloric restriction in anorexia nervosa and binge eating in bulimia nervosa and binge eating disorder, but may also serve as biomarkers of increased risk for developing an eating disorder. We focus on studies examining gut dysbiosis, peripheral inflammation, and neuroinflammation in each of these eating disorders, and explore the available data from preclinical rodent models of anorexia and binge-like eating that may be useful in providing a better understanding of the biological mechanisms underlying eating disorders. Such knowledge is critical to developing novel, highly effective treatments for these often intractable and unremitting eating disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据