4.7 Review

Gastrointestinal Vagal Afferents and Food Intake: Relevance of Circadian Rhythms

期刊

NUTRIENTS
卷 13, 期 3, 页码 -

出版社

MDPI
DOI: 10.3390/nu13030844

关键词

vagal afferents; circadian; food intake; gastrointestinal tract

资金

  1. Australian National Health and Medical Research Council (NHMRC) [APP1046289]

向作者/读者索取更多资源

Gastrointestinal vagal afferents play a crucial role in regulating food intake, under the control of circadian rhythms. Disruption of these rhythms by factors like diet-induced obesity and shift work can be mitigated by time-restricted feeding, offering a potential strategy to reset diurnal rhythms.
Gastrointestinal vagal afferents (VAs) play an important role in food intake regulation, providing the brain with information on the amount and nutrient composition of a meal. This is processed, eventually leading to meal termination. The response of gastric VAs, to food-related stimuli, is under circadian control and fluctuates depending on the time of day. These rhythms are highly correlated with meal size, with a nadir in VA sensitivity and increase in meal size during the dark phase and a peak in sensitivity and decrease in meal size during the light phase in mice. These rhythms are disrupted in diet-induced obesity and simulated shift work conditions and associated with disrupted food intake patterns. In diet-induced obesity the dampened responses during the light phase are not simply reversed by reverting back to a normal diet. However, time restricted feeding prevents loss of diurnal rhythms in VA signalling in high fat diet-fed mice and, therefore, provides a potential strategy to reset diurnal rhythms in VA signalling to a pre-obese phenotype. This review discusses the role of the circadian system in the regulation of gastrointestinal VA signals and the impact of factors, such as diet-induced obesity and shift work, on these rhythms.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据