期刊
NUTRIENTS
卷 13, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/nu13020656
关键词
sarcopenia; inflammatory bowel disease; muscle mass; exercise; nutrition
资金
- NIHR Birmingham Biomedical Research Centre
- University Hospitals Birmingham NHS Foundation Trust
- University of Birmingham
Sarcopenia, commonly seen in patients with inflammatory bowel disease, has a significant impact on the management of IBD, affecting quality of life, prognosis, and treatment. Research is ongoing to develop interventions to counteract sarcopenia in various chronic inflammatory diseases.
Malnutrition is a common condition encountered in patients with inflammatory bowel disease (IBD) and is often associated with sarcopenia (the reduction of muscle mass and strength) which is an ever-growing consideration in chronic diseases. Recent data suggest the prevalence of sarcopenia is 52% and 37% in Crohn's disease and ulcerative colitis, respectively, however it is challenging to fully appreciate the prevalence of sarcopenia in IBD. Sarcopenia is an important consideration in the management of IBD, including the impact on quality of life, prognostication, and treatment such as surgical interventions, biologics and immunomodulators. There is evolving research in many chronic inflammatory states, such as chronic liver disease and rheumatoid arthritis, whereby interventions have begun to be developed to counteract sarcopenia. The purpose of this review is to evaluate the current literature regarding the impact of sarcopenia in the management of IBD, from mechanistic drivers through to assessment and management.
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