期刊
JOURNAL OF COSMETIC DERMATOLOGY
卷 20, 期 7, 页码 2015-2019出版社
WILEY
DOI: 10.1111/jocd.14055
关键词
lipidomics; regulate; sebum; sex hormones; skin condition
类别
The study confirmed the regulatory effect of hormones on sebocytes, with androgens inducing the synthesis and secretion of more fatty acids and triglycerides, while this process is inhibited by estrogens. Hormones appear to have a dominant role in regulating sebocytes.
Background The regulation of sebocytes by hormones has been unanimously certified by scholars. But how sebocytes are affected has not been fully demonstrated by the regulation of multiple hormones. Aims The regulation effect of sex hormone on sebocytes was further discussed. Patients/Methods Based on our previous studies, the changes of skin surface liposomes in different sex hormone levels were analyzed by comprehensive statistics. Results We found that androgen can induce sebocytes to synthesis and secrete more fatty acids (FAs) and triglycerides (TGs) through comprehensive analysis of sebum content and composition, which is inhibited by estrogen. Conclusions We further confirmed the regulatory effect of hormones on sebocytes from a molecular point of view using lipidomics and found that sex hormones may dominate.
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