期刊
CANCER DISCOVERY
卷 11, 期 5, 页码 1052-1066出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-20-1227
关键词
-
类别
资金
- Canadian Institutes of Health Research
- Canadian Cancer Society
- Ontario Institute of Cancer Research
- Ontario Ministry of Research and Innovation
- Princess Margaret Cancer Centre Foundation
- Ministry of Long Term Health and Planning in the Province of Ontario
- Canadian Institutes of Health
- Garron Family Cancer Center, Hospital for Sick Children
- Canadian Cancer Society [704121]
- Canadian Institutes of Health Research [166038]
- Leukemia & Lymphoma Society grant [R6509]
- Maria H. Bacardi Chair in Transplantation
Mitochondrial and metabolic pathways play a central role in controlling gene expression to promote tumor development, progression, and immune evasion, highlighting new areas of cancer biology and potential therapeutic strategies.
Mitochondria are involved in many biological processes including cellular homeostasis, energy generation, and apoptosis. Moreover, mitochondrial and metabolic pathways are interconnected with gene expression to regulate cellular functions such as cell growth, survival, differentiation, and immune recognition. Metabolites and mitochondrial enzymes regulate chromatin-modifying enzymes, chromatin remodeling, and transcription regulators. Deregulation of mitochondrial pathways and metabolism leads to alterations in gene expression that promote cancer development, progression, and evasion of the immune system. This review highlights how mitochondrial and metabolic pathways function as a central mediator to control gene expression, specifically on stem cell functions, differentiation, and immune response in leukemia. Significance: Emerging evidence demonstrates that mitochondrial and metabolic pathways influence gene expression to promote tumor development, progression, and immune evasion. These data highlight new areas of cancer biology and potential new therapeutic strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据