期刊
ENVIRONMENTAL HEALTH PERSPECTIVES
卷 124, 期 11, 页码 1785-1793出版社
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
DOI: 10.1289/EHP208
关键词
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资金
- European Community's Seventh Framework Programme (FP7) as part of the Environmental Health Risks in European Birth Cohorts project [226285, 241604]
- Instituto de Salud Carlos III [CD12/00563, G03/176, CB06/02/0041, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647, 11/01007, 11/02591, CP11/00178, FIS-PI06/0867, FIS-PS09/00090]
- Netherlands Organization for Health Research and Development [2100.0076, VIDI 016.136.361]
- Swedish Heart-Lung Foundation
- Stockholm County Council
- Swedish Research Council for Health, Working Life and Welfare
- European Commission's Seventh Framework 29 Program: the Mechanisms of the Development of Allergy [261357]
- Danish Epidemiology of Science Centre
- Pharmacy Foundation
- Egmont Foundation
- March of Dimes Birth Defect Foundation
- Agustinus Foundation
- Health Foundation
- Erasmus Medical Center Rotterdam
- European Commission Seventh Framework Programme
- Contaminant Mixtures and Human Reproductive Health Project [212502]
- European Research Council [ERC-2014-CoG-648916]
- Programa Operacional de Saude - Saude XXI
- Administracao Regional de Saude Norte (Regional Department of Ministry of Health)
- Portuguese Foundation for Science and Technology
- Fundo Europeu de Desenvolvimento Regional
- Spanish Ministry of Health [FIS-07/0252, FIS-PI041436, FIS- PI081151, FIS-PI042018, FIS-PI09/02311]
- European Union Commission [QLK4-1999-01422, QLK4-2002-00603, FP7-ENV-212502]
- Consejeria de Salud de la Junta de Andalucia [183/07, 0675-2010]
- European Union [FP7-ENV-2011, 282957, HEALTH. 2010.2.4.5-1]
- Conselleria de Sanitat Generalitat Valenciana
- Generalitat de Catalunya [CIRIT1999SGR, 00241]
- Obre Social Cajastur
- Universidad de Oviedo
- Department of Health of the Basque Government [2005111093, 2009111069]
- Provincial Government of Gipuzkoa [DFG06/004, DFG08/001]
- European Commission [FP6-036224]
- Norwegian Ministry of Health
- National Institutes of Health
- National Institute of Environmental Health Sciences [N01-ES-85433]
- National Institute of Neurological Disorders and Stroke [1 UO1 NS 047537]
- Norwegian Research Council
- Functional Genomics [151918/S10]
- Environmental Exposures and Health Outcomes [213148]
- Compagnia San Paolo Foundation
- Piedmont Region
- National Institute of Health and Medical Research
- French Ministry of Health
- French Ministry of Labor
- French Agency for Food, Environmental and Occupational Health and Safety
- French National Research Agency
- French Institute for Public Health Surveillance
- National Centre for Research and Development, Poland [PBZ-MEiN-/8/2/2006, K140/P01/2007/1.3.1.1]
- Norwegian Financial Mechanism within the Polish-Norwegian Research Fund [PNRF-218-AI-1/07]
- European Community's Seventh Framework Programme (Fp7) [603946]
- European Union Integrated Project NewGeneris, 6th Framework Programme [FOOD-CT-2005-016320]
- Health Impacts of Long-term Exposure to Disinfection By-products in Drinking Water project [Food-CT-2006-036224]
- Calouste Gulbenkian Foundation
- Quadro Comunitario de Apoio III
- Developing a Child Cohort Research Strategy for Europe project
BACKGROUND: Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth. OBJECTIVES: We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery. METHODS: Using individual participant data from 133,957 mother-child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates. RESULTS: Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation. CONCLUSION: Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW.
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