期刊
CELL DEATH & DISEASE
卷 12, 期 3, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41419-021-03527-9
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资金
- National Institutes of Health Research senior investigator award
- Horizon 2020 grants for EU [101003544-CoNVat]
- EU [101003551 -EXSCALATE4CoV]
- Ricerca Corrente
- Finalizzata from the Ministry of Health [COVID-2020-12371817, COVID-2020-12371675]
- AIRC [IG2018-21880]
- Regione Lazio (Gruppi di ricerca) [E56C18000460002]
- Russian Government Program for the Recruitment of the Leading Scientists into the Russian Institutions of Higher Education [14.W03.31.0029]
- European and Developing Countries Clinical Trials Partnership the EU Horizon 2020 Framework Programme for Research and Innovation
The pathogenesis of SARS-CoV-2 is not entirely understood, but our study revealed profound ultrastructural changes in the infected cells and lungs of deceased COVID-19 patients, particularly involving the presence of abundant lipid droplets. This suggests a potential role of lipids in the pathogenesis of SARS-CoV-2 and highlights a new avenue for pharmacological treatment to combat the virus.
The pathogenesis of SARS-CoV-2 remains to be completely understood, and detailed SARS-CoV-2 cellular cytopathic effects requires definition. We performed a comparative ultrastructural study of SARS-CoV-1 and SARS-CoV-2 infection in Vero E6 cells and in lungs from deceased COVID-19 patients. SARS-CoV-2 induces rapid death associated with profound ultrastructural changes in Vero cells. Type II pneumocytes in lung tissue showed prominent altered features with numerous vacuoles and swollen mitochondria with presence of abundant lipid droplets. The accumulation of lipids was the most striking finding we observed in SARS-CoV-2 infected cells, both in vitro and in the lungs of patients, suggesting that lipids can be involved in SARS-CoV-2 pathogenesis. Considering that in most cases, COVID-19 patients show alteration of blood cholesterol and lipoprotein homeostasis, our findings highlight a peculiar important topic that can suggest new approaches for pharmacological treatment to contrast the pathogenicity of SARS-CoV-2.
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