期刊
JOURNAL OF MOLECULAR CELL BIOLOGY
卷 13, 期 6, 页码 409-421出版社
OXFORD UNIV PRESS
DOI: 10.1093/jmcb/mjab001
关键词
DNA-RNA hybrid; glioma; lncRNA; p53; transcription
类别
资金
- National Natural Science Foundation of China (NSFC) [81830043]
In human glioma, the long noncoding RNA OIP5-AS1 determines the specificity of p53-driven POX expression by binding to the POX promoter. This interaction is essential for POX expression and affects glioma development.
Transcription factors (TFs) control an array of expressed genes. However, the specifics of how a gene is expressed in time and space as controlled by a TF remain largely unknown. Here, in TRPC6-regulated proline oxidase 1 (POX) transcription in human glioma, we report that OIP5-AS1, a long noncoding RNA, determines the specificity of p53-driven POX expression. The OIP5-AS1/ p53 complex via its 24 nucleotides binds to the POX promoter and is necessary for POX expression but not for p21 transcription. An O-site in the POX promoter to which OIP5-AS1 binds was identified that is required for OIP5-AS1/p53 binding and POX transcription. Blocking OIP5-AS1 binding to the O-site inhibits POX transcription and promotes glioma development. Thus, the OIP5-AS1/O-site module decides p53-controlled POX expression as regulated by TRPC6 and affects glioma development.
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