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HUMAN MOLECULAR GENETICS (2015)
Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 (APE1/Ref-1) Redox Function Negatively Regulates NRF2
Melissa L. Fishel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration
Valentina Castillo et al.
PLOS ONE (2015)
Novel roles for protein disulphide isomerase in disease states: a double edged sword?
Sonam Parakh et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2015)
Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease
Stewart Siyan Cao et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
New Insights on NOX Enzymes in the Central Nervous System
Zeynab Nayernia et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
Mitochondria and redox homoeostasis as chemotherapeutic targets
Margaret M. Briehl et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2014)
Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis
Wenzhi Tan et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement
Sylvie Bannwarth et al.
BRAIN (2014)
The thioredoxin antioxidant system
Jun Lu et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis
Ernesto Miquel et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking
Manal A. Farg et al.
HUMAN MOLECULAR GENETICS (2014)
Oxidation of the Tryptophan 32 Residue of Human Superoxide Dismutase 1 Caused by Its Bicarbonate-dependent Peroxidase Activity Triggers the Non-amyloid Aggregation of the Enzyme
Fernando R. Coelho et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis
Julie D. Atkin et al.
JOURNAL OF NEUROCHEMISTRY (2014)
NADPH oxidase (NOX2) activity is a modifier of survival in ALS
Giuseppe Marrali et al.
JOURNAL OF NEUROLOGY (2014)
Oral Treatment with CuII(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Blaine R. Roberts et al.
JOURNAL OF NEUROSCIENCE (2014)
Potential Effect of S-Nitrosylated Protein Disulfide Isomerase on Mutant SOD1 Aggregation and Neuronal Cell Death in Amyotrophic Lateral Sclerosis
Gye Sun Jeon et al.
MOLECULAR NEUROBIOLOGY (2014)
Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
Ashley E. Frakes et al.
NEURON (2014)
Exome-wide Rare Variant Analysis Identifies TUBA4A Mutations Associated with Familial ALS
Bradley N. Smith et al.
NEURON (2014)
7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis
Orhan Tansel Korkmaz et al.
NEUROSCIENCE LETTERS (2014)
Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice
Renzo Mancuso et al.
NEUROTHERAPEUTICS (2014)
Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS
Kathrin Meyer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43
Radu Stoica et al.
NATURE COMMUNICATIONS (2014)
RNA metabolism in ALS: When normal processes become pathological
Cristian A. Droppelmann et al.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2014)
Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients
Koji Abe et al.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2014)
Resveratrol Ameliorates Motor Neuron Degeneration and Improves Survival in SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
Lin Song et al.
BIOMED RESEARCH INTERNATIONAL (2014)
Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: Pooled results from 5 cohort studies
Kathryn C. Fitzgerald et al.
ANNALS OF NEUROLOGY (2013)
Thioredoxin and Thioredoxin Target Proteins: From Molecular Mechanisms to Functional Significance
Samuel Lee et al.
ANTIOXIDANTS & REDOX SIGNALING (2013)
Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
Candice E. Paulsen et al.
CHEMICAL REVIEWS (2013)
Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis
Emanuele D'Amico et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice
Erica D. Koval et al.
HUMAN MOLECULAR GENETICS (2013)
Ubiquilin 2 mutations in Italian patients with amyotrophic lateral sclerosis and frontotemporal dementia
Cinzia Gellera et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2013)
Keap1 Is Localized in Neuronal and Glial Cytoplasmic Inclusions in Various Neurodegenerative Diseases
Kunikazu Tanji et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2013)
Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial
Merit E. Cudkowicz et al.
LANCET NEUROLOGY (2013)
Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis
Bruce Morgan et al.
NATURE CHEMICAL BIOLOGY (2013)
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons
Wen-Yuan Wang et al.
NATURE NEUROSCIENCE (2013)
The changing scene of amyotrophic lateral sclerosis
Wim Robberecht et al.
NATURE REVIEWS NEUROSCIENCE (2013)
Glutathione and thioredoxin dependent systems in neurodegenerative disease: What can be learned from reverse genetics in mice
Marcus Conrad et al.
NEUROCHEMISTRY INTERNATIONAL (2013)
Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels
Fernando Bartolome et al.
NEURON (2013)
Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
Shuo-Chien Ling et al.
NEURON (2013)
Redox Regulation in Amyotrophic Lateral Sclerosis
Sonam Parakh et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)
Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation
C. Parisi et al.
CELL DEATH & DISEASE (2013)
A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
Isaac M. Chiu et al.
CELL REPORTS (2013)
Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic
Youn-Bok Lee et al.
CELL REPORTS (2013)
Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis
Erin J. McAllum et al.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2013)
Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis
John Ravits et al.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2013)
The Physiological Functions of Mammalian Endoplasmic Oxidoreductin 1: On Disulfides and More
Thomas Ramming et al.
ANTIOXIDANTS & REDOX SIGNALING (2012)
Amyotrophic Lateral Sclerosis: New Insights into Underlying Molecular Mechanisms and Opportunities for Therapeutic Intervention
Mauro Cozzolino et al.
ANTIOXIDANTS & REDOX SIGNALING (2012)
Posttranslational Modification of Cysteine in Redox Signaling and Oxidative Stress: Focus on S-Glutathionylation
John J. Mieyal et al.
ANTIOXIDANTS & REDOX SIGNALING (2012)
Autophagy Dysregulation in Amyotrophic Lateral Sclerosis
Sheng Chen et al.
BRAIN PATHOLOGY (2012)
Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking
Todd J. Cohen et al.
EMBO JOURNAL (2012)
Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS
Bing Liao et al.
EXPERIMENTAL NEUROLOGY (2012)
A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: Therapeutic implications for ALS
Takuya Kanno et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Human Protein-disulfide Isomerase Is a Redox-regulated Chaperone Activated by Oxidation of Domain a′
Chao Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis
Chi-Hong Wu et al.
NATURE (2012)
The C9orf72 hexanucleotide repeat expansion in FTD and ALS
Eileen H. Bigio
NATURE REVIEWS NEUROLOGY (2012)
Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase
Manal A. Farg et al.
NEUROBIOLOGY OF AGING (2012)
Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype
Matthis Synofzik et al.
NEUROBIOLOGY OF AGING (2012)
UBQLN2/ubiquilin 2 mutation and pathology in familial amyotrophic lateral sclerosis
Kelly L. Williams et al.
NEUROBIOLOGY OF AGING (2012)
Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies
Yohei Iguchi et al.
NEUROBIOLOGY OF DISEASE (2012)
An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1
Stefania Guareschi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice
H. Z. Yin et al.
CELL DEATH & DISEASE (2012)
Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases
William M. Johnson et al.
NUTRIENTS (2012)
Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease
Dapeng Zhang et al.
Frontiers in Genetics (2012)
Protein disulfide isomerase-immunopositive inclusions in patients with amyotrophic lateral sclerosis
Yasuyuki Honjo et al.
AMYOTROPHIC LATERAL SCLEROSIS (2011)
Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases
Tohru Fukai et al.
ANTIOXIDANTS & REDOX SIGNALING (2011)
SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
Faisal Fecto et al.
ARCHIVES OF NEUROLOGY (2011)
Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice
David R. Beers et al.
BRAIN BEHAVIOR AND IMMUNITY (2011)
Proteomic approaches to the characterization of protein thiol modification
Edward T. Chouchani et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2011)
Neurotoxic 43-kDa TAR DNA-binding Protein (TDP-43) Triggers Mitochondrion-dependent Programmed Cell Death in Yeast
Ralf J. Braun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Alsin and SOD1G93A Proteins Regulate Endosomal Reactive Oxygen Species Production by Glial Cells and Proinflammatory Pathways Responsible for Neurotoxicity
Qiang Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model
Cynthia P. W. Soon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways
Vivek Swarup et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
Han-Xiang Deng et al.
NATURE (2011)
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
Amanda M. Haidet-Phillips et al.
NATURE BIOTECHNOLOGY (2011)
Bcl2-A1 interacts with pro-caspase-3: Implications for amyotrophic lateral sclerosis
Ciro Iaccarino et al.
NEUROBIOLOGY OF DISEASE (2011)
Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
Mariely DeJesus-Hernandez et al.
NEURON (2011)
A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
Alan E. Renton et al.
NEURON (2011)
An Overview of DNA Repair in Amyotrophic Lateral Sclerosis
Fabio Coppede
THESCIENTIFICWORLDJOURNAL (2011)
TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies
Todd J. Cohen et al.
TRENDS IN MOLECULAR MEDICINE (2011)
Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form
Aaron Kerman et al.
ACTA NEUROPATHOLOGICA (2010)
Structure, Function, and Mechanism of Thioredoxin Proteins
Jean-Francois Collet et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis
Adam K. Walker et al.
BRAIN (2010)
Differential expression and alternative splicing of genes in lumbar spinal cord of an amyotrophic lateral sclerosis mouse model
Huifang Chen et al.
BRAIN RESEARCH (2010)
Extracellular Mutant SOD1 Induces Microglial-Mediated Motoneuron Injury
Weihua Zhao et al.
GLIA (2010)
Cysteine Function Governs Its Conservation and Degeneration and Restricts Its Utilization on Protein Surfaces
Stefano M. Marino et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
Sami J. Barmada et al.
JOURNAL OF NEUROSCIENCE (2010)
Mutations of optineurin in amyotrophic lateral sclerosis
Hirofumi Maruyama et al.
NATURE (2010)
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
Daryl A. Bosco et al.
NATURE NEUROSCIENCE (2010)
Broad clinical phenotypes associated with TAR-DNA binding protein (TARDBP) mutations in amyotrophic lateral sclerosis
Janine Kirby et al.
NEUROGENETICS (2010)
Capturing VCP: Another Molecular Piece in the ALS Jigsaw Puzzle
Christopher E. Shaw
NEURON (2010)
MUTANT TAR DNA-BINDING PROTEIN-43 INDUCES OXIDATIVE INJURY IN MOTOR NEURON-LIKE CELL
W. Duan et al.
NEUROSCIENCE (2010)
Loss of ALS2/Alsin Exacerbates Motor wDysfunction in a SOD1H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking
Shinji Hadano et al.
PLOS ONE (2010)
Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase
John Mitchell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Thiol-Based Redox Switches in Eukaryotic Proteins
Nicolas Brandes et al.
ANTIOXIDANTS & REDOX SIGNALING (2009)
Signaling Components of Redox Active Endosomes: The Redoxosomes
Fredrick D. Oakley et al.
ANTIOXIDANTS & REDOX SIGNALING (2009)
Redox Modifier Genes and Pathways in Amyotrophic Lateral Sclerosis
Barrie J. Carter et al.
ANTIOXIDANTS & REDOX SIGNALING (2009)
Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases
Thomas L. Leto et al.
ANTIOXIDANTS & REDOX SIGNALING (2009)
Protein Disulfide Isomerase: A Critical Evaluation of Its Function in Disulfide Bond Formation
Feras Hatahet et al.
ANTIOXIDANTS & REDOX SIGNALING (2009)
Differential regulation of neuronal and inducible nitric oxide synthase (NOS) in the spinal cord of mutant SOD1 (G93A) ALS mice
Junghee Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: Use of APE1 small molecule inhibitors to delineate APE1 functions
Yanlin Jiang et al.
DNA REPAIR (2009)
Arimoclomol: a potential therapy under development for ALS
Veena Lanka et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)
Quantification of protein modification by oxidants
Clare L. Hawkins et al.
FREE RADICAL BIOLOGY AND MEDICINE (2009)
Microglia in ALS: The Good, The Bad, and The Resting
Jenny S. Henkel et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2009)
Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
Caroline Vance et al.
SCIENCE (2009)
Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
T. J. Kwiatkowski et al.
SCIENCE (2009)
A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease
Richard W. Orrell et al.
AMYOTROPHIC LATERAL SCLEROSIS (2008)
ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth
Asako Otomo et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Ero1 and redox homeostasis in the endoplasmic reticulum
Carolyn S. Sevier et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)
Biological effects of CCS in the absence of SOD1 enzyme activation: implications for disease in a mouse model for ALS
Jody B. Proescher et al.
HUMAN MOLECULAR GENETICS (2008)
SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model
Maged M. Harraz et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1G93A mouse model of ALS
Bernadett Kalmar et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis
Alexander Sarlette et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Koji Yamanaka et al.
NATURE NEUROSCIENCE (2008)
Oxidant-antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease
G. Nagesh Babu et al.
NEUROCHEMISTRY INTERNATIONAL (2008)
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
Jemeen Sreedharan et al.
SCIENCE (2008)
Novel Mutations in TARDBP(TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis
Nicola J. Rutherford et al.
PLOS GENETICS (2008)
Increased ER stress during motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis
Tetsuya Nagata et al.
NEUROLOGICAL RESEARCH (2007)
Redox modifier genes in amyotrophic lateral sclerosis in mice
Jennifer J. Marden et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1
Jun-ichi Niwa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Whole-genome analysis of sporadic amyotrophic lateral sclerosis
Travis Dunckley et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Tryptophan 32 potentiates aggregation and cytotoxicity of a copper/zinc superoxide dismutase mutant associated with familial amyotrophic lateral sclerosis
David M. Taylor et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
Francesco Paolo Di Giorgio et al.
NATURE NEUROSCIENCE (2007)
Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes
Carolina Jancic et al.
NATURE CELL BIOLOGY (2007)
Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo
L. Chi et al.
NEUROSCIENCE (2007)
The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
Karen Bedard et al.
PHYSIOLOGICAL REVIEWS (2007)
Free radicals and antioxidants in normal physiological functions and human disease
Marian Valko et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
Insoluble mutant SOD1 is partly oligoubiquitinated in amyotrophic lateral sclerosis mice
Manuela Basso et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Neuronal intermediate filaments and ALS: A new look at an old question
Shangxi Xiao et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2006)
Effect of nitric oxide on lymphocytes from sporadic amyotrophic lateral sclerosis patients: toxic or protective role?
C. Cereda et al.
NEUROLOGICAL SCIENCES (2006)
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Manuela Neumann et al.
SCIENCE (2006)
Neuroprotective effects of (-)-epigallocatechin-3-gallate in a transgenic mouse model of amyotrophic lateral sclerosis
Zhihao Xu et al.
NEUROCHEMICAL RESEARCH (2006)
Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials
Alberto Ferri et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy
Yo Sasaki et al.
JOURNAL OF NEUROSCIENCE (2006)
The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice
Du-Chu Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen
Clare A. Wood-Allum et al.
BRAIN (2006)
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
Arnaud Jacquier et al.
ANNALS OF NEUROLOGY (2006)
Vitamin E intake and quality of life in amyotrophic lateral sclerosis patients: a follow-up case series study
A. Galbussera et al.
NEUROLOGICAL SCIENCES (2006)
Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities
R. S. Devon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Onset and progression in inherited ALS determined by motor neurons and microglia
Severine Boillee et al.
SCIENCE (2006)
S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
Takashi Uehara et al.
NATURE (2006)
Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria
HX Deng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice
Y Furukawa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Chronic activation in presymptornatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL
C Raoul et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A two-stage design for a phase II clinical trial of coenzyme Q10 in ALS
G Levy et al.
NEUROLOGY (2006)
The effect of epigallocatechin gallate on suppressing disease progression of ALS model mice
SH Koh et al.
NEUROSCIENCE LETTERS (2006)
Regulation of NADPH oxidases - The role of Rac proteins
PL Hordijk
CIRCULATION RESEARCH (2006)
Mapping superoxide dismutase 1 domains of non-native interaction: roles of intra- and intermolecular disulfide bonding in aggregation
J Wang et al.
JOURNAL OF NEUROCHEMISTRY (2006)
The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress
S Chakravarthi et al.
EMBO REPORTS (2006)
The endoplasmic reticulum: Folding, calcium homeostasis, signaling, and redox control
Agnes Goerlach et al.
ANTIOXIDANTS & REDOX SIGNALING (2006)
Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS
KL Ferrante et al.
NEUROLOGY (2005)
Redox-dependent transcriptional regulation
HJ Liu et al.
CIRCULATION RESEARCH (2005)
Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress
HB Cai et al.
JOURNAL OF NEUROSCIENCE (2005)
Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice - A model of familial amyotrophic lateral sclerosis
HF Poon et al.
FREE RADICAL BIOLOGY AND MEDICINE (2005)
Redox system expression in the motor neurons in amyotrophic lateral sclerosis (ALS): immunohistochemical studies on sporadic ALS, superoxide dismutase 1 (SOD1)-mutated familial ALS, and SOD1-mutated ALS animal models
S Kato et al.
ACTA NEUROPATHOLOGICA (2005)
Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS
J Kirby et al.
BRAIN (2005)
High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study
M Graf et al.
JOURNAL OF NEURAL TRANSMISSION (2005)
A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death
K Kanekura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Amyotrophic Lateral Sclerosis: New Developments in Diagnostic Markers
Reinhard Dengler et al.
NEURODEGENERATIVE DISEASES (2005)
Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants
K Kanekura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis
R Rakhit et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice
D Kieran et al.
NATURE MEDICINE (2004)
Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor
JD Topp et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis
CW Strey et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Unraveling the mechanisms involved in motor neuron degeneration in ALS
LI Bruijn et al.
ANNUAL REVIEW OF NEUROSCIENCE (2004)
Epigallocatechin gallate prevents oxidative-stress-induced death of mutant Cu/Zn-superoxide dismutase (G93A) motoneuron cells by alteration of cell survival and death signals
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TOXICOLOGY (2004)
Oxidation of ER resident proteins upon oxidative stress: Effects of altering cellular redox/antioxidant status and implications for protein maturation
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ANTIOXIDANTS & REDOX SIGNALING (2003)
Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells
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AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2003)
Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains
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CELLULAR AND MOLECULAR LIFE SCIENCES (2003)
Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes
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AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS (2003)
Protein kinase and protein phosphatase expression in the central nervous system of G93A mSOD over-expressing mice
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JOURNAL OF NEUROCHEMISTRY (2003)
Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase are susceptible to disulfide reduction
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis
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ANNALS OF NEUROLOGY (2002)
Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis
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CELL DEATH AND DIFFERENTIATION (2002)
Induction of pro inflammatory molecules in mice with amyotrophic lateral sclerosis:: No requirement for proapoptotic interleukin-1β in neurodegeneration
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ANNALS OF NEUROLOGY (2001)
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis
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NATURE GENETICS (2001)
Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans
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HUMAN MOLECULAR GENETICS (2001)
A double-blind, placebo-controlled randomized clinical trial of α-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis
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AMYOTROPHIC LATERAL SCLEROSIS (2001)
Functional characterization of Ape1 variants identified in the human population
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NUCLEIC ACIDS RESEARCH (2000)
A method for detecting abasic sites in living cells: Age-dependent changes in base excision repair
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
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