期刊
FRONTIERS IN CELLULAR NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2021.637784
关键词
glutamate transport; EAAT; astrocyte; metabolic stress; ischemia; stroke; excitotoxicity
资金
- DFG [SFB1089 B03, SPP1757 HE6949/1, FOR2795, HE6949/3, HE6949/5, SPP 1757 RO2327/8-2, FOR 2795 RO2327/13-1, FOR 2795 RO2327/14-1, FOR 2795 PE1193/6-1]
- DZNE
High-affinity, Na+-dependent glutamate transporters play a crucial role in removing synaptically released glutamate, thus increasing spatial precision of synaptic communication. Dysfunction of these transporters can lead to elevated glutamate concentration, enhanced spread, and potentially neuronal death.
High-affinity, Na+-dependent glutamate transporters are the primary means by which synaptically released glutamate is removed from the extracellular space. They restrict the spread of glutamate from the synaptic cleft into the perisynaptic space and reduce its spillover to neighboring synapses. Thereby, glutamate uptake increases the spatial precision of synaptic communication. Its dysfunction and the entailing rise of the extracellular glutamate concentration accompanied by an increased spread of glutamate result in a loss of precision and in enhanced excitation, which can eventually lead to neuronal death via excitotoxicity. Efficient glutamate uptake depends on a negative resting membrane potential as well as on the transmembrane gradients of the co-transported ions (Na+, K+, and H+) and thus on the proper functioning of the Na+/K+-ATPase. Consequently, numerous studies have documented the impact of an energy shortage, as occurring for instance during an ischemic stroke, on glutamate clearance and homeostasis. The observations range from rapid changes in the transport activity to altered expression of glutamate transporters. Notably, while astrocytes account for the majority of glutamate uptake under physiological conditions, they may also become a source of extracellular glutamate elevation during metabolic stress. However, the mechanisms of the latter phenomenon are still under debate. Here, we review the recent literature addressing changes of glutamate uptake and homeostasis triggered by acute metabolic stress, i.e., on a timescale of seconds to minutes.
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