期刊
VIRUSES-BASEL
卷 13, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/v13030443
关键词
Seoul virus; orthohantavirus; rat
类别
资金
- Dutch Ministry of Health, Welfare and Sport
The study found that Seoul virus (SEOV) is prevalent in different populations of pet and feeder rats in the Netherlands, with the highest positivity rate found in commercial breeders. The seroprevalence was largely in line with the prevalence calculated from PCR-positive rats, indicating widespread transmission of SEOV in domesticated rats in Europe.
Seoul virus (SEOV) is a zoonotic orthohantavirus carried by rats. In humans, SEOV can cause hemorrhagic fever with renal syndrome. Recent human SEOV cases described in the USA, United Kingdom, France and the Netherlands were associated with contact with pet or feeder rats. The prevalence of SEOV in these types of rats is unknown. We collected 175 pet and feeder rats (Rattus norvegicus) from private owners, ratteries and commercial breeders/traders in the Netherlands. Lung tissue of the rats was tested using a SEOV real-time RT-qPCR and heart fluid was tested for the presence of antibodies against SEOV. In all three investigated groups, RT-qPCR-positive rats were found: in 1/29 rats from private owners (3.6%), 2/56 rats from ratteries (3.4%) and 11/90 rats from commercial breeders (12.2%). The seroprevalence was largely similar to the prevalence calculated from RT-qPCR-positive rats. The SEOV sequences found were highly similar to sequences previously found in domesticated rats in Europe. In conclusion, SEOV is spread throughout different populations of domesticated rats.
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