4.6 Article

Characterization of the GBoV1 Capsid and Its Antibody Interactions

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Summary: Human bocaviruses (HBoVs) infect children and immunocompromised individuals, resulting in respiratory and gastrointestinal infections. This study compared the capsid structures of HBoV2 with previously determined HBoV1, HBoV3, and HBoV4, revealing strain and genus-specific features contributing to tissue tropism and antigenicity. Additionally, analyzing HBoV1 and HBoV2 structures under acidic conditions provided insights into capsid changes associated with endosomal and gastrointestinal acidification, unraveling the molecular mechanism of HBoV infection.

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