期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 47, 期 3, 页码 693-709出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2020.10.010
关键词
Drug delivery; Intravascular ultrasound; Theragnostic ultrasound; Catheter delivery of Definity; Cavitation nucleation
资金
- U.S. National Institutes of Health [R01 HL135092]
The study aimed to investigate whether the EkoSonic endovascular system could sustain cavitation nucleated by infused Definity, to support subsequent studies of ultrasound-mediated drug delivery to diseased arteries. The results showed that the 2.0 mL/min infusion rate yielded the highest surviving Definity concentration and acoustic attenuation.
The EkoSonic endovascular system has been cleared by the U.S. Food and Drug Administration for the controlled and selective infusion of physician specified fluids, including thrombolytics, into the peripheral vasculature and the pulmonary arteries. The objective of this study was to explore whether this catheter technology could sustain cavitation nucleated by infused Definity, to support subsequent studies of ultrasound-mediated drug delivery to diseased arteries. The concentration and attenuation spectroscopy of Definity were assayed before and after infusion at 0.3, 2.0 and 4.0 mL/min through the EkoSonic catheter. PCI was used to map and quantify stable and inertial cavitation as a function of Definity concentration in a flow phantom mimicking the porcine femoral artery. The 2.0 mL/min infusion rate yielded the highest surviving Definity concentration and acoustic attenuation. Cavitation was sustained throughout each 15 ms ultrasound pulse, as well as throughout the 3 min infusion. These results demonstrate a potential pathway to use cavitation nucleation to promote drug delivery with the EkoSonic endovascular system. (E-mail: Christy.Holland@uc.edu) (C) 2020 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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