Understanding Host-Pathogen-Vector Interactions with Chronic Asymptomatic Malaria Infections

The last malaria parasite standing will display effective adaptations to selective forces. While substantial progress has been made in reducing malaria mortality, eradication will require elimination of all Plasmodium parasites, including those in asymptomatic infections. These typically chronic, low-density infections are difficult to detect, yet can persist for months. We argue that asymptomatic infection is the parasite's best asset for survival but it can be exploited if studied as a new model for host-pathogen-vector interactions. Regular sampling from cohorts of asymptomatic individuals can provide a means to investigate continuous parasite development within its natural host. State-of-the-art techniques can now be applied to such infections. This approach may reveal key molecular drivers of chronic infections - a critical step for malaria eradication.

Automated summary

The survival of malaria parasites heavily relies on asymptomatic infections, which can be exploited as a new model for host-pathogen-vector interactions. Regular sampling from asymptomatic individuals provides insights into the continuous development of parasites within their natural hosts. State-of-the-art techniques can now be applied to study chronic infections and potentially reveal key molecular drivers necessary for malaria eradication.