期刊
TRENDS IN PARASITOLOGY
卷 37, 期 6, 页码 468-475出版社
CELL PRESS
DOI: 10.1016/j.pt.2021.01.007
关键词
-
类别
资金
- Swiss National Science Foundation [PZ00P3_168080]
- Natural Sciences and Engineering Council of Canada [RGPIN201606602]
- Swiss National Science Foundation (SNF) [PZ00P3_168080] Funding Source: Swiss National Science Foundation (SNF)
Helminth secretomes contain many potential immunomodulators that play essential roles at the host-parasite interface. The mechanisms of action of anthelmintic drugs, such as benzimidazoles and macrocyclic lactones, are still not fully understood. By combining insights from various fields of parasitology research, new strategies for altering the host-parasite interface in the search for novel anthelmintic approaches may be developed.
Helminth secretomes comprise many potential immunomodulators. The molecular and functional diversity of these entities and their importance at the host-parasite interface have been increasingly recognized. It is now common to hypothesize that parasite-derived molecules (PDMs) are essential mediators used by parasites to establish and remain in their hosts. Suppression of PDM release has been reported for two anthelmintic drug classes, the benzimidazoles and macrocyclic lactones, the mechanisms of action of which remain incompletely resolved. We propose that bringing together recent insights from different streams of parasitology research, for example, immunoparasitology and pharmacology, will stimulate the development of new ways to alter the host-parasite interface in the search for novel anthelmintic strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据