Extracellular Vesicles and Biomaterial Design: New Therapies for Cardiac Repair

There is increasing evidence that extracellular vesicles (EVs) mediate the paracrine effects of stem cells. Although EVs have several attractive characteristics, they also raise issues related to delivery. For patients with cardiac disease that require a surgical procedure, direct intramyocardial (IM) administration of EVs is straightforward but its efficacy may be limited by fast wash-out, hence the interest of incorporating EVs into a controlled release polymer to optimize their residence time. For patients without surgical indication, the intravenous (IV) route is attractive because of its lack of invasiveness; however, whole-body distribution limits the fraction of EVs that reach the heart, hence the likely benefits of EV engineering to increase EV homing to the target tissue.

Automated summary

EVs play a crucial role in the paracrine effects of stem cells, but face challenges in delivery such as fast wash-out and whole-body distribution limits. Researchers are exploring different administration routes to enhance the residence time and targeting of EVs in the target tissue.