Sensory Nerves Regulate Transcriptional Dynamics of Lymph Node Cells

The nervous system plays important roles in homeostasis and inflammatory responses in tissues. However, the regulation of lymph nodes (LN) by nerves remains largely unknown. Huang et al. demonstrate that LNs are innervated by unique peptidergic nociceptors that signal to various endothelial, stromal, and immune cell types in LNs.

Automated summary

The nervous system plays crucial roles in maintaining tissue homeostasis and regulating inflammatory responses. Recent studies have shown that lymph nodes are innervated by unique peptidergic nociceptors, signaling to various cell types within the lymph nodes.