Elimination of Senescent Endothelial Cells: Good or Bad Idea?

Cellular senescence has a critical role in many physiopathological contexts. Recent studies highlight the beneficial and adverse effects that eliminating senescent endothelial cells can have on health span, questioning the current development of drugs that induce the death of senescent cells, named senolytics, as a therapeutic strategy.

Automated summary

Cellular senescence plays a critical role in various physiological and pathological contexts. Recent studies have highlighted the dual effects that eliminating senescent endothelial cells can have on health span. This raises questions about the current development of senolytics as a therapeutic strategy.