Reciprocal Links between Pre-messenger RNA 3′-End Processing and Genome Stability

The 3 '-end processing of most pre-messenger RNAs (pre-mRNAs) involves RNA cleavage and polyadenylation and is coupled to transcription termination. In both yeast and human cells, pre-mRNA 3 '-end cleavage is globally inhibited by DNA damage. Recently, further links between pre-mRNA 3 '-end processing and the control of genome stability have been uncovered, as reviewed here. Upon DNA damage, various genes related to the DNA damage response (DDR) escape 3 '-end processing inhibition or are regulated through alternative polyadenylation (APA). Conversely, various pre-mRNA 3 '-end processing factors prevent genome instability and are found at sites of DNA damage. Finally, the reciprocal link between pre-mRNA 3 '-end processing and genome stability control seems important because it is conserved in evolution and involved in disease development.

Automated summary

The 3'-end processing of pre-mRNAs is globally inhibited by DNA damage in yeast and human cells. There are complex links between pre-mRNA 3'-end processing and the control of genome stability. When DNA damage occurs, genes related to the DNA damage response may escape processing inhibition or be regulated through alternative polyadenylation. Additionally, pre-mRNA 3'-end processing factors play a role in preventing genome instability at sites of DNA damage.